Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1992-10-07
1994-10-18
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424423, 424426, 514886, 514863, A61K 9127, A61K 3722
Patent
active
053566335
ABSTRACT:
A method of and composition for concentrating a therapeutic agent in an inflamed dermal region are disclosed. The composition, which is also used in the method, is a liposomal composition. The liposomes contain the therapeutic agent in entrapped form and are composed of vesicle-forming lipids including a vesicle-forming lipid derivatized with hydrophilic biocompatible polymer. After intravenous administration, the liposomes are taken up by the inflamed region within 24-48 hours, for site-specific release of entrapped compound into the inflamed region.
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Huang Shi K.
Martin Francis J.
Woodle Martin C.
Dehlinger Peter J.
Liposome Technology, Inc.
Page Thurman K.
Spear James M.
Stratford Carol A.
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