Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1992-03-27
1998-12-01
Levy, Neil
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
514 78, 514 62, A61K 9127
Patent
active
058434739
ABSTRACT:
A method of treating a site of systemic infection which includes administering a therapeutic compound entrapped in liposomes. Also included is a liposomal composition and a method of preparing a liposomal composition for use in concentrating a therapeutic compound to an infected region via the bloodstream. The liposomes, which contain the agent in entrapped form, are composed of vesicle-forming lipids, a vesicle-forming lipid derivatized with hydrophilic biocompatible polymer, and have sizes in a selected size range between 0.07 and 0.2 microns. After parenteral administration, the liposomes are selectively taken up by the infected region within 24-48 hours, for release of entrapped compound into the infected region.
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Bakker-Woudenberg Irma A.J.M.
Martin Francis J.
Woodle Martin C.
Dehlinger Peter J.
Levy Neil
Sequus Pharmaceuticals, Inc.
Stratford Carol A.
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