Method of treatment of gastroesophageal reflux disease by enhanc

Details Method of treatment of gastroesophageal reflux disease by enhanc Method of treatment of gastroesophageal reflux disease by enhanc

1996-08-16

1998-03-24

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Chewing gum type

424441, 424485, A61K 968, A61K 928, A61K 914

Patent

active

057309582

ABSTRACT:
Prolonged mastication is demonstrated to enhance salivary secretion as well as enhance secretion of salivary components such as salivary bicarbonate, epidermal growth factor, mucin, PGE.sub.2 and transforming growth factor.sub..alpha.. Mastication beginning prior to about 30 minutes in advance of any meal may reduce sensations of heartburn in patients and has therapeutic value in the treatment of patients with reflux esophagitis and gastroesophageal reflux disease. Post-meal chewing is of additional value in alleviating severe symptoms.

REFERENCES:
patent: 5154927 (1992-10-01), Song et al.
patent: 5424084 (1995-06-01), Schmidt et al.
patent: 5541165 (1996-07-01), Turgeon

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