Method of treatment of diabetes mellitus by administration of ad

Details Method of treatment of diabetes mellitus by administration of ad Method of treatment of diabetes mellitus by administration of ad

1994-01-04

1996-08-20

Kunz, Gary L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 46, A61K 3170, C07H 19167

Patent

active

055479421

ABSTRACT:
The administration of adenine nucleotides or adenosine and inorganic phosphate to a human patient results in the generation of elevated liver, other organs and red blood cell adenosine 5'-triphosphate (ATP) pools as well as increased levels of ATP in the extracellular blood plasma compartment of the blood. The present invention deals with the utilization of the elevated extracellular levels of ATP for achieving the well-established stimulation of insulin secretion following the interactions of extracellular ATP pools with pancreatic .beta. cell purine receptors. The invention is therefore concerned with the treatment of patients suffering from non-insulin-dependent diabetes mellitus (NIDDM or Type-II diabetes) and their chronic clinical complications which are the result of continuous hyperglycemia, by the administration of these physiological agents.

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patent: 5284834 (1984-02-01), Jacobson et al.
Loubatieres-Mariani et al. Eur. J. Pharmacol. 59:277-286, 1979.

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