Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1997-07-28
2000-05-02
MacMillan, Keith B.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241411, 4241301, 514 2, A61K 39395
Patent
active
060569581
ABSTRACT:
This invention relates to a method of prevention and/or treatment of thrombosis in a mammal without significantly altering bleeding time or coagulation. This invention further relates to methods of using selective inhibitors of the binding of vitronectin to the .alpha..sub.v .beta..sub.3 receptor, alone or in combination with other therapeutic agents, for the inhibition of thrombus formation and/or the treatment of thromboembolic disorders.
REFERENCES:
Charo et al, Journal of Biological Chemistry, vol. 262 (21), Jul. 25, 1987, pp. 9935-9938.
Yue, Tian-Li; McKenna, Patrick J.; Ohlstein, Eliot H.; Farach-Carson, Mary C.; Butler, William T.; Johanson, Kyung; McDevitt, Patrick; Feuerstein, Giora Z.; and Stadel, Jeffrey M., Exp. Cell Res. 1994, 214, 459, "Osteopontin-Stimulated Vascular Smooth Muscle Cell Migration Is Mediated by .beta..sub.3 Integrin".
Shaker A. Mousa et al., Circulation, 1994, 89 (1), 3, "Antiplatelet and Antithrombotic Efficacy of DMP 728, a Novel Platelet GPIIb/IIIa Receptor Antagonist".
Rote, William E.; Mu, Dun Xue; Bates, Eric R.; Nedelman, Mark A.; and Luchesi, Benedict R., Journal of Cardiovascular Pharmacology, 1994, 23:194-202, "Prevention of Rethrombosis After Coronary Thrombolysis in a Chronic Canine Model. I. Adjunctive Therapy with Monoclonal Antibody 7E3 F(ab').sub.2 Fragment".
Dupont Pharmaceuticals
MacMillan Keith B.
Rubin Kenneth B.
Vance David H.
Wessendorf T. D.
LandOfFree
Method of treatment of arterial and venous thromboembolic disord does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treatment of arterial and venous thromboembolic disord, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treatment of arterial and venous thromboembolic disord will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1591948