Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1993-02-25
1994-01-04
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Lymphokine
53038825, A61K 39395, C07K 1528
Patent
active
052758125
ABSTRACT:
The present invention relates to a novel treatment for myocardial infarction which comprises administering a hapten-binding molecule capable of preventing reformation of fibrin-platelet clots and a thrombolytic agent capable of either dissolving fibrin-platelet clots or inhibiting their formation. The therapy of the invention is capable of increasing clot lysis while minimizing fibrinogen breakdown and preventing the reocclusion of the affected coronary artery. The therapy of the present invention is capable of achieving this goal even in the absence of heparin and when the concentration of thrombolytic agent is lower than that required by other potential therapies.
REFERENCES:
patent: 4172124 (1979-10-01), Kaprowski
patent: 4258030 (1981-03-01), Sasaki et al.
patent: 4305926 (1981-12-01), Everse et al.
patent: 4471053 (1984-09-01), Comi et al.
patent: 4568544 (1986-02-01), Hasegawa et al.
patent: 4772585 (1988-09-01), Sarnoff et al.
Ganz, W., et al., J. Amer. Coll. Cardiol. 1:1247-1253, (1983).
Rentrop, K. P., et al., Amer. J. Cardiol. 54:29E-31E, (1984).
Gold, H. K., et al., Amer. J. Cardiol. 53:122C-125C, (1984).
Kunicki, T. J., et al., Blood Cells, 9:293-301 (1983).
Kunicki, T. J., et al., J. Immunol., 126:398-402 (1981).
Coller, B. S., et al., J. Lab. Clin. Med., 107: 384-392, 1986.
Coller, B. S., et al., Blood, 66: 1456-1459 (1985).
Kohler, H., et al., Nature, 256; 495-497, (1975).
Eldor, A., et al., Blood, 65:1477-1483 (1985).
Coller, B. S., et al., Blood, 68:783-786 (1986).
Garabedian, H. A., et al., J. Amer. Coll. Cardiol., 9:599-607 (1987).
Coller, B. S., et al., Blood, 61:99-110 (1983).
Oster, Z. H., et al., proc. Natl. Acad. Sci., (USA) 82:3465-3468 (1985).
Yesuda, T., et al., Clin. Res., 34:643A (1986).
Eisen, H. N., (In: Microbiology, 3rd ed., Davis, B. D., et al., Harper & Row, N.Y. pp. 342-349 (1980).
DiMinno, G., et al., Arteriosclerosis 6:203-211 (1986).
Coller, B. S., J. Clin. Invest., 76: 101-108, (1985).
Ganong, W. F., (In: Review of Medical Physiology, 9th ed., Lange, Los Altos, Calif., pp. 411-414 (1979).
Nachman, R. L., et al., J. Clin. Invest, 69: 263-269 (1982).
Coller, B. S., et al., J. Clin. Invest., 72: 325-338 (1983).
Gold, H. K., et al., Circulation, 68: Supp I, I-50-I-54 (1983).
Verstraete, M., et al., Lancet 1:142 (1985).
Gold, H. K., et al., Circulation, 73:347-352 (1986).
Callewaert, Chem Abs.; 103: 129039u, 1985.
Muzykantov et al., Chem Abs., 107: 81648c, 1986.
Ohlstein et al, Chem Abs, 107,: 32932z, 1987.
Collen Desire
Coller Barry S.
Gold Herman K.
Loring Susan A.
The General Hospital Corporation
The Research Foundation of State University of New York
Wax Robert A.
LandOfFree
Method of treatment for myocardial infarction does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treatment for myocardial infarction, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treatment for myocardial infarction will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-305147