Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1994-08-12
1999-02-23
MacMillan, Keith D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514895, 514452, 514289, 514415, 514392, A61K 31135
Patent
active
058744770
ABSTRACT:
The invention provides a method of preventing or treating malaria comprising administering a therapeutically effective amount of serotonin receptor ligand to reduce the pathological consequences of malaria infection in a patient, said serotonin receptor ligand characterized by an ability to displace an identifying ligand which defines the serotonin receptor subtype 5HT1a or 5HT2/5HT1c.
In addition, the invention provides a method of identifying a serotonin receptor ligand capable of reducing the pathological consequences of malarial infection in a patient comprising the step of sequentially assaying potential ligands to identify a ligand characterized by an ability to displace an identifying ligand which defines the serotonin receptor subtype 5HT1a or 5HT2/5HT1c.
REFERENCES:
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Agarwal, et al, Chemical Abstracts, vol. 14, No. 2. pp. 237-245 (1993) "3-D QSAR for intrinsic activity of 5-HT1A receptor ligands by the method of comparative molecular field analysis", abstract No. 118:204695, J. Comput. Chem., 14(2), pp. 237-245.
Harrington, et al. Medline Abstracts, vol. 268. No. 3, pp. 1098-1106 (1994) "Agonist-induced Desensitization and loss of high-affinity binding sites of stably expressed human 5-HT1A receptors", abstract No. 94186960, J. Pharmacol. Exp. Ther., 268(3), pp. 1098-1106.
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Chemical Abstract 118:204695 Agarwal et al, "3-D QSAR for intrinsic activity of 5-HT1A receptor ligands by the method of comparative receptor field analysis", J. Comput. Chem. 14(2), 1993, 237-45.
Locher Christopher P.
McConnell Bruce
Kleinsmith David F.
MacMillan Keith D.
Reiter Stephen E.
The University of Hawaii
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