Method of treatment and prophylaxis of venous thrombosis

Details Method of treatment and prophylaxis of venous thrombosis Method of treatment and prophylaxis of venous thrombosis

1995-06-07

1998-05-05

Lukton, David

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 530331, 548535, A61K 3805

Patent

active

057474605

ABSTRACT:
The invention relates to new competitive inhibitors of thrombin, their synthesis, pharmaceutical compositions containing the compounds as active ingredients, and the use of the compounds as anticoagulants for prophylaxis and treatment of thromboembolic diseases, according to the formula ##STR1## wherein A represents a methylene group, an ethylene group or a propylene group, which may be substituted or

REFERENCES:
patent: 4346078 (1982-08-01), Bajusz
patent: 5037819 (1991-08-01), Han
patent: 5110812 (1992-05-01), Han
Chemical Abstracts, Vol. 99, No. 25, 19 Dec 1983 (Columbus, Ohio, USA), Bajusz, Sandor et al, "Inhibition of Thrombin with H- and Boc-D-Phe-Pro-Agm," p. 21, Abstract No. 205609.

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