Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2008-03-11
2008-03-11
Romeo, David (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C435S377000
Reexamination Certificate
active
11100716
ABSTRACT:
The present invention relates generally to a method of treatment and in particular a method of treating disorders of the nervous system such as arising from or during disease or injury. The method of the present invention involves manipulating expression of Eph receptors or their functional equivalents to increase or decrease expression or function depending on the condition being treated.
REFERENCES:
Martone et al., Brain research, (Oct. 17, 1997) vol. 771, No. 2, pp. 238-250.
Goldshmit et al., “Axonal Regeneration and Lack of Astrocytic Gliosis in EphA4-Deficient Mice,”The Journal of Neuroscience, 24(45): 10064-10073, Nov. 10, 2004.
Dottori, et al. “EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract”,Proc. Natl. Acad. Sci. USA, vol. 95, pp. 13248-13253, Oct. 1998.
Zhou, “The Eph Family Receptors and Ligands”,Pharmacol Ther., vol. 77, No. 3, pp. 151-181, 1998.
Bartlett Perry F.
Boyd Andrew W.
Coonan Jason
Dottori Mirella
Galea Mary P.
Foley and Lardner LLP
Gamett Daniel C
Romeo David
The Council of the Queensland Institute of Medical Research
The University of Melbourne
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