Method of treating viral infections with amino acid analogs

Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid

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424422, 514 2, 514885, A61K 9127

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active

051106000

ABSTRACT:
Retrovirally-infected cells are selectively killed as compared with uninfected cells using an effective amount of amino acid analogs of naturally occurring amino acids, such as L-canavanine (an analog of arginine).

REFERENCES:
patent: 3804776 (1974-04-01), Yazawa et al.
patent: 4185090 (1980-01-01), McIntire
patent: 4338335 (1982-07-01), McAleer et al.
patent: 4377567 (1982-03-01), Geho
patent: 4400295 (1983-08-01), Odtsu et al.
patent: 4638045 (1987-01-01), Kohn et al.
patent: 4713244 (1987-12-01), Bawa et al.
patent: 4717716 (1988-01-01), Nagai et al.
patent: 4744989 (1988-05-01), Payne et al.
patent: 4752425 (1988-06-01), Martin et al.
patent: 4755388 (1988-07-01), Heath et al.
patent: 4761288 (1988-08-01), Mezei
patent: 4774320 (1988-09-01), Tagliabue et al.
patent: 4795739 (1989-01-01), Lifson et al.
patent: 4855090 (1989-08-01), Wallach
patent: 4871488 (1989-10-01), Mannino et al.
patent: 4883661 (1989-11-01), Daly et al.
Mitsuya et al., "Strategies for antiviral therapy in AIDS" Nature, 325:773-778 (1987).
G. A. Rosenthal, "The biological effects and mode of action of L-Canavanine, a structural analogue of L-Arginine", Qt. Rev. Biol., 52:155-178 (1977).
Cummings et al., "Structural aberations in T-even bacteriophage. ill. induction of lollipops and their partial characterization", Virology 54:245-261 (1973).
Schachtele et al., "Canavanine death in Escherichia coli", J. Mol. Biol., 14:474-489 (1965).
Neurath et al., "Inhibition of adenovirus replication by Canavanine", Biochem. Biophys. Res. Commun., 41: 1509-1517 (1970).
McMahon et al., "The effects of Canavanine and arginine starvation on macromolecular synthesis in Chlamydomonas reinhardi", J. Gen. Microbiol., 73:239-250 (1972).
Kruse et al., "Incorporation of Canavanine into protein of Walker carcinosarcoma 256 cells cultured in Vitro", Cancer Res., 19:122-125 (1959).
Dahlman et al., "Further studies of the effect of L-Canavanine on the tobacco hornworm, Manduca sexta", J. Insect Physiol., 22:265-271 (1976).
D. Bell, "The effect of Canavanine on herpes simplex virus replication", J. Gen. Virol., 22:319-330 (1974).
W. F. Prouty, "Degradation of abnormal proteins in HeLa cells", J. Cell Physiol., 88:371-382 (1976).
Goldberg et al., "Intercellular protein degradation in mammalian and bacterial cells: part 2", Ann. Rev. Biochem., 45:747-803 (1976).
Green et al., "Antitumor activity of L-Canavanine against L1210 Murine leukemia", Cancer Research 40:535:537 (1980).
Berjis et al., "Selective cytotoxicity of L-Canavanine in tumorigenic Madin-Darby canine kidney T.sub.1 cells", Interactions, 60:305-315 (1986).
Thomas et al., "Growth inhibition of a rat colon tumor by L-Canavanine", Cancer Research, 46:2898-2903 (1986).
Malinow et al., "Systemic lupus erythematosus-like syndrome in monkeys fed alfalfa sprouts: role of a nonprotein amino acid", Science, 216:415-417 (1982).
B. D. Noe, "Inhibition of islet prohormone to hormone conversion by incorporation of arginine and lysine analogs", J. Biol. Chem., 250:7623-7630 (1975).
Christner et al., "Inhibition of the assembly and secretion of procollagen by incorporation of a Thereonine analogue, Hydroxynorvaline", J. Biol. Chem., 250:7623-7630 (1975).
Green et al., "Enhancement of human tumor cell killing by L-Canavanine in combination with .gamma.-radiation", Cancer Res., 43:4180-4182 (1983).
Thomas et al., "Toxicity and pharmacokinetics of the nonprotein amino acid L-Canavanine in the rat", Toxicology and Applied Pharmacology, 91:395-405 (1987).
Yarchoan et al., "Development of antiretroviral therapy for the acquired immunodeficiency syndrome and related disorders", New England J. of Med., 316(9):557-563 (1987).
Kaplan et al., "Treatment of patients with acquired immunodeficiency syndrome and associated manifestations", JAMA, 257(10): 1367-1374 (1987).
Naha et al., "Reappraisal of L-Canavanine as an anti-tumor agent", Cell Biology Internatl. Rpts., 4(2) 155-165 (1980).

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