Method of treating viral infections

Details Method of treating viral infections Method of treating viral infections

1993-09-07

1996-12-17

Weimar, Elizabeth C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 514 21, A61K 3921

Patent

active

055853498

ABSTRACT:
The invention provides a method of treating a viral infection in a mammal comprising administering an effective amount of modified C-reactive protein (CRP) to the mammal. In particular, modified-CRP has been found to be effective and safe for treating retroviral infections, including human immunodeficiency virus 1. The invention also provides a method of neutralizing a virus comprising contacting the virus with modified-CRP. In particular, modified-CRP can be used to neutralize viruses in blood which is to be used for transfusions by adding the modified-CRP to the blood prior to the transfusion.

REFERENCES:
R. L. Shoeman et al, Medical Hypotheses, vol. 37, pp. 137-150 (1992).
G. Pantaleo and A. Fauci, F. of NIH Research, vol. 5, pp. 68-73 (1993).
A. S. Fauci, Science, vol. 262, pp. 1011-1018 (1993).
Medical Microbiology, 2nd Ed., ed. Samuel Baron, MD, Addison-Wesley, Pub, Inc, pp. 727-732 (1986).
Ammar et al. J. Clin Invest, '87(6), 2048-55, Biological and Biochemical Characterization . . . normal T cells.
Rudd et al PNAS, '85 pp. 5190-5194, Jul. 1988.
"The CD4 recepton . . . T lymphocytes".
Atono et al., Gastroenterologia Japonica, 24, 655-662 (1989).
Ballou et al., J. Lab. Clin. Med., 115, 332-38 (1990).
Barna et al., Cancer Research, 44, 305-310 (1984).
Bray et al., Clin. Immunol. Newsletter, 8, 137-140 (1987).
Chase, "Doctors and Patients Hope AZT Will Help Stave Off AIDS," Wall Street Journal, Apr. 28, 1988, p. 14, col. 1.
Chem. Eng. News, Oct. 14,1991, at 17.
Chicago Tribune, Nov. 15, 1991, section 1, p. 5.
Chu et al., Proc. Amer. Acad. Cancer Res., 29, 371a (1988).
Chu et al., Proc. Amer. Acad. Cancer Res., 28, 344a (1987).
Chudwin et al., J. Allergy Clin. Immunol., 77, 216a (1986).
Dagani, Chem. Eng. News, Nov. 23, 1987, at 41-49.
Deodhar et al., Cancer Research, 42, 5084-5088 (1982).
Fauci, Science, 239, 617-622 (1988).
Fauci et al., Ann. Intern. Med., 114, 678-693 (1991).
Gotschlich, Ann. N.Y. Acad. Sci., 557, 9-18 (1989).
Gupta et al., J. Immunol., 137, 2173-79 (1986).
Hokama et al., J. Bacteriology, 83, 1017-1024 (1962).
Horowitz et al., J. Immunol., 138, 2598-2603 (1987).
Hu et al., J. Biol. Chem., 263, 1500-1504 (1988).
Hu et al., Biochem., 25, 7834-39 (1986).
Hull et al, Virology: Directory & Dictionary of Animal, Bacterial and Plant Viruses, p. 191 (Stockton Press 1989).
James et al., Dissertation Abstracts International, 41/08-B, 2963 (1980).
Kempka et al., J. Immunol., 144, 1004-1009 (1990).
Kilpatrick and Volanakis, Immunol. Res., 10, 43-53 (1991).
Kilpatrick and Volanakis, J. Immunol., 134, 3364-70 (1985).
Kindmark, Clin. Exp. Immunol., 8, 941-48 (1971).
Lei et al., J. Biol. Chem., 260, 13377-83 (1985).
Mantzouranis et al., Ped. Res., 18, 260a (1984).
Mold et al., Infection and Immunity, 38, 392-395 (1982).
Mold et al., Ann. N.Y. Acad. Sci., 389, 251-62 (1982).
Montefiori et al., Proc. Nat'l Acad. Sci. U.S.A., 84, 2985-89 (1987).
Nakayama et al., Clin. Exp. Immunol., 54, 319-26 (1983).
Nakayama et al., J. Immunol., 132, 1336-40 1984).
Potempa et al., Mol. Immumol., 20, 1165-75 (1983).
Potempa et al. Mol. Immunol., 24, 531-41 (1987).
Potempa et al., Proc. Amer. Acad. Cancer Res., 28, 344a (1987).
Potempa et al., Protides Biol. Fluids, 34, 287-290 (1986).
Potempa et al., Inflammation, 12, 391-405 (1988).
Potempa et al., FASEB J., 2, 731a (1988).
Putto et al., Archives of Disease in Childhood, 61, 24-29 (1986).
Reed and Muench, Amer. J. Hygiene, 27, 493 (1938).
Rees et al., Fed. Proc., 45, 263a (1986).
Samols and Hu, Protides Biol. Fluids, 34, 263-66 (1986).
Samols et al., Biochem. J., 227, 759-65 (1985).
Tebo et al., J. Immunol., 144, 231-38 (1990).
Thombre et al., Cancer Immunol. Immunother., 16, 145-150 (1984).
Tillett and Francis, J. Exp. Med., 52, 561-71 (1930).
Volanakis et al., J. Immunol., 113, 9-17 (1974).
Weislow et al., J. Natl. Cancer Inst., 81, 577-586 (1989).
Whitehead et al., Biochem. J., 266, 283-90 (1990).
Woo et al., J. Biol. Chem., 260, 13384-88 (1985).
Xia et al., FASEB J., 5, A1628 (1991).
Yarchoan et al., Anal Intern. Med., 115, 184-89 (1991).
Yarchoan et al., Immunol. Today, 11, 327-33 (1990).
Ying et al., J. Immunol., 143, 221-28 (1989).
Zeller et al., Fed. Proc., 46, 1033a (1987).

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