Method of treating viral hepatitis by administration of...

Drug – bio-affecting and body treating compositions – Lymphokine – Interferon

Reexamination Certificate

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C424S085400, C514S002600, C514S012200, C530S351000

Reexamination Certificate

active

06884411

ABSTRACT:
Use of natural human α-interferon for the preparation of a medicament in liquid form to be administered through peroral route at dosages comprised between 100 UI and 500 UI/day, for therapy of viral infections, in particular viral hepatitis, neoplasia and immune diseases in humans and animals.

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patent: 1005868 (2000-06-01), None
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Toyoda et al. Retreatment of chronic hepatitis C with interferon. Am J Gastroenterol 89(9): 1453-1457, 1994.*
Di Bisceglie et al. Recombinant interferon alfa therapy for chronic hepatitis C. New England J Med 321:1506-1510, 1989.*
Davis et al. Treatment of chronic hepatitis C with recombinant interferon alfa. New England J Med 321: 1501-1506, 1989.*
Main, J. Future studies of combination therapy for chronic hepatitis C: optimizing response rates for each hepatitis C population. J Hepatology (Suppl) 23(2): 32-36, 1995.*
Marcellin et al. Recombinant human alpha-interferon in patients with chronic non-a, non-b hepatitis: a multicenter randomized controlled trial from France. Hepatology 13: 393-397, 1991.*
Archivum Immunologiae et Therapiae Experimentalis 41(3-4). 1993: 259-265, J.A. Georgiades; “Early changes in the plasma proteins of patients treated with low doses of oral natural human interferon alpha (IFN-alpha)”.
Archivum Immunologiae et Therapiae Experimentalis 41(3-4). 1993; 237-240. B. Ratajczak; “Observation of the effect of low oral doses of human leukocytic interferon alpha in children with chronic HBV infection and impaired immune response”.
Archivum Immunologiae et Therapiae Experimentalis 44 (5-6); 1996; 359-366.; Zielinska et al: “Comparison of the long-term effects of treatment with oral and parenteral interferon alpha in chronic viral hepatitis patients”.

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