Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1996-08-21
1999-02-16
Smith, Lynette F.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
5303871, 5303883, 5303894, 4352351, 435948, A61K 3915, C07K 1600, C12N 700, C12N 100
Patent
active
058717480
ABSTRACT:
A method of producing active immunity against a viral disease in an animal subject comprises administering to the subject a vaccine conjugate consisting essentially of a live virus and a neutralizing factor bound to the live virus. The neutralizing factor is selected from the group consisting of antibodies and antibody fragments. The live virus is one capable of producing disease in the subject, and the antibody or antibody fragment is one capable of neutralizing the live virus. Preferred subjects are birds, a preferred virus is Infectious Bursal Disease Virus, and a preferred route of administration to birds is by in ovo administration.
REFERENCES:
patent: 2518978 (1950-08-01), Cox et al.
patent: 3326767 (1967-06-01), Holper et al.
patent: 3651213 (1972-03-01), Wallis et al.
patent: 3846543 (1974-11-01), Fields et al.
patent: 3853467 (1974-12-01), Giaever
patent: 4092116 (1978-05-01), Giaever
patent: 4458630 (1984-07-01), Sharma et al.
patent: 4493825 (1985-01-01), Platt et al.
patent: 4530831 (1985-07-01), Lutticken et al.
patent: 4614793 (1986-09-01), Hughes et al.
patent: 4645665 (1987-02-01), Aoontoweil et al.
patent: 4659569 (1987-04-01), Mitsuhashi et al.
patent: 4743562 (1988-05-01), Rasmussen et al.
patent: 4761282 (1988-08-01), Apontoweil et al.
patent: 4824668 (1989-04-01), Melchior, Jr. et al.
patent: 4867975 (1989-09-01), Gelb, Jr.
patent: 4956452 (1990-09-01), Snyder et al.
patent: 5057314 (1991-10-01), Whitfill et al.
K.J. Fahey, et al; A Conformation Immunogen on RP-2 of Infectious Bursal Disease Virus that induces Virus-neutralizing Antibodies that Passively Protect Chickens, J. Gen. Virol. 70, 1473-1481 (1989).
P.N. Sharma, et al; Role of Maternal Antibodies in Immunization of Chicks Against Newcastle Disease Virus, Zootechnica International (Jun. 1989).
T. Mitsui, et al; Combined hepatitis B Immune Globulin and Vaccine for Postexposure Prophylaxis of Accidental Hepatitis B Virus Infection in Hemodialysis Staff Members: Comparison with Immune Globulin without Vaccine in Historical Controls, Hepatology 10, pp. 324-327 (1989).
R.E. Randall, Solid matrix-antibody-antigen (SMAA) complexes for constructing multivalent subunit vaccines, Immunology Today 10, No. 10, pp. 336-339 (1989).
R.E. Randall, et al; Immunization against Multiple Viruses by Using Solid-Matrix-Antibody-Antigen Complexes, Journal of Virology 63 No. 4, pp. 1808-1810 (1989).
A.C.R. Chambers, et al; Location of a Neutralizing Epitope for the Haemagglutinin-Neuraminidase Glycoprotein of Newcastle Disease Virus, J. Gen. Virol 69, pp. 2115-2122 (1988).
R.E. Randall, et al; Humoral and Cytotexic T Cell Immune Responses to Internal and External Structural Proteins of Simian Virus 5 Induced by Immunication with Solid Matrix-Antibody-Antigen Complexes, J. Gen. Virol 69, pp. 2505-2515 (1988).
N. Gyles and C. Whitfill; Annual Report of Project Contributions to NE-60 (Oct. 1987).
N. Gyles and C. Whitfill; Annual Report of Project Contributions to NE-60 (Oct. 1986).
D. Weitz, et al; Neutralization of Poliovirus by Polyclonal Antibodies Requires Binding of a Single IgG Molecule per Viron, Arch Virol 91, pp. 207-220 (1986).
G. Meulemans, et al; Protective Effects of HN and F Glycoprotein-Specific Monoclonal Antibodies on Experimental Newcastle Disease, Avian Pathology 15, pp. 761-768 (1986).
P.A. Abdu, et al; Infectious Bursal Disease, Worlds Poultry Science 42, pp. 219-231 (1986).
N.J. Chettle, et al; Comparison of Virus Neutralizing and Precipitating Antibodies to Infectious Bursal Disease Virus and Their Effect on Susceptibility to Challenge, Br.vet.J. 141, pp. 146-150 (1985).
J.J. Giambrone and R.P. Clay; Evaluation of the Immunogenicity, Stability, Pathogenicity, and Immunodepressive Potential of Four Commercial Live Infectious Bursal Disease Vaccines, Poultry Science 65, pp. 1287-1290 (1986).
S.A. NAQI, et al; Maternal Antibody and its Effect on Infectious Bursal Disease Immunization, Avian Diseases 27,No. 3, pp. 623-631 (1982).
Hagan and Bruner 7th Ed. pp. 673-676 (1981).
The Merck Manual, 2nd Ed. p. 311 (1981).
D.A. Higgins, Interaction of Lentogenic Newcastle Disease Virus and Specific Antibodies Within the Yolk SAC, Avian Diseases 14, pp. 579-586 (1970).
D.A. Higgins, Vccination Response of Parentally Immune Chicks After Yolk-SAC Inoculation of the Embryo With Inactivated Newcastle Disease Virus, Avian Diseases pp. 98-101 (1970).
P.G. Box et al; Newcastle Disease 1. The Use of Egg Yolk Derived Antibody for Passive Immunisation of Chickens, J. Comp. Path 79, pp. 475-506 (1969).
H.D. Stone and W.A. Boney; Vaccination of congenitally-Immune Chicks against Newcastle Disease Virus (33057), PSEB Med. 128, pp. 525-530 (1968).
S.L. Morrison and G. Terres; Enhanced Immunologic Sensitization of Mice by the Simultaneous Injection of Antigen and Specific Antiserum, The Journal of Immunology 96 No. 5; pp. 901-905 (1966).
P.J. Vasington, et al; Studies on the Protective Value of newcastle-Immune Serum and Gamma Globulin Against Artificially Induced Newcastle Disease of Chickens, Poultry Science 39, pp. 1418-1427 (1960).
G. Terres and W. Wolins; Enhanced Sensitization in Mice by Simultaneous Injection of Antigen and Specific Rabbit Antiserum, pp. 632-635.
P.J. Vasington; Studies on the Serologicl Response to and Protective Value of Immune Serum and Gamma Globulin in Chickens Artificially Inoculated with Newcastle Disease Virus, Masters Thesis, University of Maryland (1959).
L.A. Phillips, et al; Trials on passive immunization and treatment of Newcastle disease by use of plasma and Vitelo Hiperinmunes, La Vida Agricola, pp. 111-120 (Feb. 1956).
Harlow, et al.: Antibodies-a laboratory manual: pp. 141-163, 1988.
Roitt et al, Immunology, Gowe-Medical Publishing, London 1985, pp. 5.2 & 5.7.
Fredericksen Tommy L.
Thaxton, Jr. J. Paul
Thoma John A.
Tyczkowski Julius K.
Whitfill Craig E.
Embrex, Inc
Nelson Brett L.
Smith Lynette F.
The University of Arkansas
LandOfFree
Method of treating viral diseases in animals does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treating viral diseases in animals, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating viral diseases in animals will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2059730