Method of treating ulcers and erosions in the gastrointestinal s

Details Method of treating ulcers and erosions in the gastrointestinal s Method of treating ulcers and erosions in the gastrointestinal s

1985-09-09

1986-11-18

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

A61K 3170

Patent

active

046236414

ABSTRACT:
A new method is disclosed for the treatment and prevention of gastrointestinal ulcers or erosions which comprises the administration of a pharmaceutically effective amount of a PGI.sub.2 methyl ester-beta cyclodextrin complex to a patient in need of said treatment wherein the amount of the PGI.sub.2 methyl ester constitutes 1 to 15% by weight of the complex.

REFERENCES:
patent: 4070537 (1978-01-01), Hayashi et al.
patent: 4117119 (1978-09-01), Kurono et al.
patent: 4232009 (1980-11-01), Hayashi et al.
patent: 4351846 (1982-09-01), Matsumoto et al.
Stadler-Szoke et al, A Forecast for Application of Cyclodextrins in the Pharma-Industry, Proc. First Int. Symp. on Cyclodextrins, p. 377 (1981).
Whittle et al., Actions of--PGI.sub.2 . . . on the Rat Gastric Mucosa, Chem. Abstracts, 89: 123544a (1978).
Szejtlip et al., Inclusion Complexes of Prostacyclin . . . with Cyclodextrin, Chem. Abstracts, 91: 62728f (1979).
Hayashi et al., Preparations Containing Prostaglandin Analogs, Chem. Abstracts, 90: 127526g (1978).

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