Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Food or edible as carrier for pharmaceutical
Reexamination Certificate
2000-10-26
2003-10-28
Page, Thurman K. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Food or edible as carrier for pharmaceutical
C424S725000, C424S745000, C424S746000, C514S925000, C514S927000
Reexamination Certificate
active
06638523
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to a method of treating ulcers comprising administering an effective amount of a particular ingredient contained in a certain plant, for example plants belonging to the Labiatae family, as an effective ingredient to a subject having such ulcers.
DESCRIPTION OF THE PRIOR ART
Rosemary, alternatively referred to as “Mannenrou”, which is a plant belonging to the Labiatae family, is widely used in the West as a herb for medicinal, fragrant and cooking purposes. The effectiveness of rosemary when used for medicinal purposes has been variously described for a long time. For example, the compile version (1983) of the British Herbal Pharmacopoeia has described that rosemary has carminative, analgesic, microbicidal, antiseptic, abirritant, diuretic, antimicrobial effects and the like. Also, according to recent Japanese patent publications, a deodorant effect (JP-A-04/173070), an anti-caries effect (JP-A-04/13630), an antioxidant effect (JP-A-03/197595), antiviral and antineoplastic effects (JP-A-04/247054), and a hair growth stimulating effect (JP-A-04/18026) have been disclosed. Furthermore, various effects of an essential oil of rosemary have been numerously reported in the past (for example, the effectiveness of rosemary in aromatotherapy, aromatopia, No.4, p.47). In addition, effects of several components contained in rosemary have been also clarified. For example, Japanese patent publication JP-A-08/119872 clarifies that a Helicobacter growth-inhibiting effect of rosemary extract is attributable to rosmanol or carvacrol contained in the extract.
It is also known that sage, alternatively referred to as “salvia”, which is a plant belonging to the Labiatae family, has carminative, antispasmodic, astringent, microbicidal, angiotelectasis, and hypoglycemic effects and the like (“Medical Herb”, Japan Vorg Company). Furthermore, according to recent Japanese patent publications, a sage extract is used in testosterone 5&agr; reductase inhibitors (JP-A-08/310923), skin cosmetics (JP-A-08/109122), metanogenesis inhibitors (JP-A-07/187988) and the like.
The present inventors have intensively searched for a plant extract having a potent curing or prophylactic effect against ulcers such as alcoholic ulcers and stress ulcers, and also intended to clarify effective ingredients contained therein.
SUMMARY OF THE INVENTION
The present inventors found, as a consequence of an intensive search, that rosemary and sage extracts have extremely potent curing and prophylactic effects against ulcers. Furthermore, the present inventors found that their effective ingredients are carnosic acid of the formula (I) below and carnosol of the formula (II) below.
Thus, the present invention provides a method of treating ulcers comprising administering an effective amount of carnosic acid and/or carnosol or a plant extract containing carnosic acid and/or carnosol as an effective ingredient to a subject having such ulcers.
Carnosic acid and/or carnosol or a plant extract containing carnosic acid and/or carnosol may be administered in the form of a drug, quasi-drug or food composition.
Also, the present invention provides a method of producing anti-ulcer drug and quasi-drug compositions comprising formulating an effective amount of carnosic acid and/or carnosol or a plant extract containing carnosic acid and/or carnosol as an effective ingredient.
Furthermore, the present invention provides a food composition comprising carnosic acid and/or carnosol, and a method of producing the food composition comprising formulating carnosic acid and/or carnosol.
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“Medical Herb”; Sage (salvia); p. 95, 1995; Japan Vorg Company.
“Aromatopia”; Effectiveness of rosemary in aromatotherapy; p. 47; 1995, Fragrance Journal Ltd.
British Herbal Pharmacopoeia; 1983; p. 180-181; (compile version).
Offord et al., Rosemary components inhibit benzo [&agr;]pyrene-induced genotoxicity in human bronchial cells, Carcinogenesis vol. 16, No. 9, P2057-2062, (1995).
Paris et al., Inhibitory effect of carnosolic acid on HIV-1 protease in cell-free assays, J. Natural Products, vol. 56, No. 8, P1426-1430, (1993).
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Aruma et al., An evaluation of the antioxidant and antiviral action of extracts of rosemary and provencal herbs, Food Chem. Toxic, No. 34, P449-456 (1996).
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Chan et al., Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production, Cancer Lett, vol. 96, No. 1, P23-29 (1995).
Laughton et al., Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives, Biochem. Pharmacol., vol. 42, No. 9, P1673-81 (1991).
Ito Hisatomi
Kosaka Kunio
Miyazaki Toshitsugu
Jacobson & Holman PLLC
Nagase & Company, Ltd.
Page Thurman K.
Sheikh Humera N.
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