Method of treating ulcerative colitis and Crohn's disease...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C530S350000, C424S085200

Reexamination Certificate

active

07005412

ABSTRACT:
Methods for regulating levels of nitric oxide are disclosed. The methods utilize IL-17 receptors, which may be used in conjunction with inhibitor IL-1 and/or TNF.

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Aarvak et al., “Analysis of IL-17 and other cytokines and surface markers of RA inflammatory T cell clones,”American College of Rheumatology(ACR) meeting, Poster 1448, Nov. 1997.
Amin, A. R. et al., “The expression and regulation of nitric oxide synthase in human osteroarthritis-affected chondrocytes: Evidence for up-regulated neuronal nitric oxide synthase,”J. Exp. Med., 182:2097-2102, Dec. 1995.
Attur, M. G. et al., “Interleukn-17 up-regulation of nitric oxide production in human osteoarthritis cartilage,”Arthritis&Rheumatism, 40(6):1050-1053, 1997.
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Jovanovic, et al., “IL-17 stimulates the secretion of proinflammatory cytokines by human macrophages,”American College of Rheumatology(ACR) meeting, Poster 1446, Nov. 1997.
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