Method of treating ulcerative colitis

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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426 72, 514867, 514925, A61K 3170, A61K 31715

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054440548

ABSTRACT:
A method of improving the nutritional status and reversing the characteristic diarrhea and inflammatory condition in a mammalian creature having ulcerative colitis or inflammation of the colon which contains in combination (a) an oil blend which contains eicosapentaenoic acid (20:5n3) and/or docosahexaenoic acid (22:6n3), and (b) a source of indigestible carbohydrate which is metabolized to short chain fatty acids by microorganisms present in the human colon. Preferably the nutritional product also contains one or more nutrients which act as antioxidants.

REFERENCES:
Rosenberg et al., "Nutritional Aspects of Inflammatory Bowel Disease", Annual Review of Nutrition, 5:463-484 (1985).
Gonzalez-Huix et al., "Enteral versus Parenteral Nutrition as Adjunct Therapy in Acute Ulcerative Colitis", The American Journal of Gastroenterology, 8:2:227-232 (1993).
Sutton, "Nutritional Needs of Children with Inflammatory Bowel Disease", Nutrition, 18:10:21-25 (1992).
Glotzer et al., "Proctitis and Colitis Following Diversion of the Fecal Stream", Gastroenterology, 80:438-441 (1981).
Komorowski, "Histolagic Spectrum of Diversion Colitis", American Journal of Surgical Pathology, 14:548-554 (1990).
Roediger, "The Starved Colon--Diminished Mucosal Nutrition, Diminished Absorption, and Colitis", Diseases of the Colon and Rectum, 33:858-862 (1990).
Harig et al., "Treatment of Diversion Colitis with Short-Chain-Fatty Acid Irrigation", New England Journal of Medicine, 320:23-28 (1989).
Roediger, "The Colonic Epithelium in Ulcerative Colitis: an Energy Deficiency Disease?", The Lancet, 2:712-715 (1980).
Vernia et al, "Fecal Lactate and Ulcerative Colitis", Gastroenterology 95:1564-1568 (1988).
Vernia et al, "Organic Anions and the Diarrhea of Inflammatory Bowel Disease", Digestive Diseases and Sciences, 33:1353-1358 (1988).
Breuer et al., "Rectal Irrigation with Short--Chain Fatty Acids for Distal Ulcerative Colitis", Digestive Diseases and Sciences, 36:185-187 (1991).
Senagore et al., "Short--Chain Fatty Acid Enemas: a Cost Effective Alternative in the Treatment of Nonspecific Proctosigmeiditis", Diseases of the Colon and Rectum, 35:923-927 (1992).
Scheppach et al., "Effect of Butyrate Enemas on the Colonic Mucosa in Distal Ulcerative Colitis", Gastroenterology, 103:51-56 (1992).
Smith et al., "Introduction to the Metabolic Activities of Intestinal Bacteria", American Journal of Clinical Nutrition, 32:149-157 (1979).
Miller et al., "Fermentations by Saccarolytic Intestinal Bacteria", American Journal of Clinical Nutrition, 32:164-172 (1979).
Cummings, "Fermentation in the Human Large Intestine:Evidence and Implications for Health", The Lancet, May 1983, pp. 1206-1209.
Titgemeyer et al., "Fermentability of Various Fiber Sources by Human Fecal Bacteria in vitro", American Journal of Clincal Nutrition, 53:1418-1424 (1991).
Salyers et al., "Fermentation of Mucin and Plant Polysaccharides by Strains of Bacteroides from the Human Colon", Applied and Environmental Microbiology, 33:319-322 (1977).
Mitsuoka et al., "Effect of Fructo-oligosaccharides on Intestinal Microflora", Die Nahrung, 31:427-436 (1987).
Tokunaya et al., "Influence of Chronic Intake of New Sweetener Fructooligosaccharide (Neosugar) on Growth and Gastrointestinal Function of the Rat", Journal of Nutritional Science and Vitaminology, 32:111-121 (1986).
Janne et al, "Colonic Mucosal Atrophy Induced by a Liquid Elemental Diet in Rats", Digestive Diseases, 22:9:808-812 (1977).
Morin et al., "Small Intestinal and Colonic Changes Induced by Changes in a Chemically Defined Diet", Digestive Diseases and Sciences, 25:2:123-128 (1980).
Sircur et al., "Effect of Synthetic Diets on Gastrointestinal Murcosal DNA Synthesis in Rats", American Journal of Physiology, 244:G327-G335 (1983).
Ryan et al., "Effects of Various Diets on Colonic Growth in Rats", Gastroenterology, 77:658-663 (1979).
Storme et al, "The Effect of a Liquid Elemental Diet on Cell Proliferation in the Colon of Rats", Cell and Tissue Research, 216:221-225 (1981).
Goodlad et al., "Proliferative effects of fibre on the intestinal Epithelium:Relationship to Gastrin, Enteroglucangon and PYY", Gut, 28:S1:221-226 (1987).
Kripe et al, "Stimulation of Intestional Mucosal Growth with Intracolonic Infusion of Short--Chain Fatty Acids", Journal of Parenteral and Enteral Nutrition, 13:2:109-116 (1989).
Sheppach et al., "Effect of Short--Chain Fatty Acids on the Human Colonic Mucosa in Vitro", Journal of Parenteral and Enteral Nutrition, 16:1:43-48 (1992).
Sakata, "Stimulatory Effect of Short--Chain Fatty Acids on Cell Proliferation in the Rat Intestine: a Possible Explanation for Trophic Effects of Fermentable Fibre, Gut Microbes and Luminal Trophic Factors", British Journal of Nutrition, 58:95-103 (1987).
Thomas et al., "Effect of Enteral Feeding on Intestinal Epithelial Proliferation and Fecal Bile Acid Profiles in the Rat", Journal of Parenteral and Enteral Nuttrition, 17:3:210-213 (1993).
Rolandelli et al., "Comparison of Parenteral Nutrition and Enteral Feeding with Pectin in Experimental Colitis in the Rat", American Journal of Clinical Nutrition, 47:715-721 (1988).
McBurney et al., "Effect of Human Faecel Innoculum on In Vitro Fermentation Variables", British Journal of Nutrition, 58:233-243 (1987).
McBurney et al., "Effect of Human Faecel Donor on In Vitro Fermentation Variables", Scandanavian Journal of Gastroenterology, 24:359-367 (1989).
Merchen et al., "Effect of Intake and Forage Level on Ruminal Turnover Rates, Bacterial Protein Synthesis and Duodenal Amino Acid Flows in Sheep", Journal of Animal Science, 62:216-225 (1986).
Barker et al., "The Colorimetric Determination of Lactic Acid in Biological Material", Journal of Biological Chemistry, 138:535-554 (1941).
Baldwin, "Energy Metabolism in Anaerobes", The American Journal of Clinical Nutrition, 23:11:1508-7513 (1970).
Ozaki et al., "Effect of Xylooligosaccharide on the Growth of Bifidobacteria", Bifidobacteria Microflora, 9:2:77-86 (1990).
Sharon et al., "Role of Prostaglandins in Ulcerative Colitis. Enhanced Production During Active Disease and Inhibition by Sulfasalazine", Gastroenterology, 75:638-640 (1978).
Ligumsky et al., "Enhanced Thrombexane Az and Prostacyclin Production by Cultured Rectal Mucosa in Ulcerative Colitis and Its Inhibition by Steroids and Sulfasalazine", Gastroenterology, 81:444-449 (1981).
Sharon et al., "Enhanced Synthesis of Leukotrine B4 by Colonic Mucosa in Inflammatory Bowel Disease", Gastroenterology, 86:453-460 (1984).
Lauritsen et al., "In Vivo Effects of Orally Administered Prednisolone on Prastaglandin and Leucotriene Production in Ulcerative Colitis", Gut 28:1095-1099 (1987).
Lauritsen et al., "In Vivo Profiles of Eicosanoids in Ulcerative Colitis, Crohn's Colitis and Clostridium Difficile Colitis", Gastroenterology, 95:1:11-17 (1988).
Seidman, "Nutritional Management of Inflammatory Bowel Disease", Gastroenterology Clinics of North America, 17:1:129-155 (1989).
Dudrick et al., "Nutritional Management of Inflammatory Bowel Disease", Surgical Clinics of North America, 7:3:609-623 (1991).
Teahon et al., "The Role of Enteral and Parenteral Nutrition in Crohn's Disease and Ulcerative Colitis", Progress in Inflammatory Bowel Disease, 12:2:1-4 (1991).
Vilaseca et al., "Participation of Thromboxane and Other Eicosanoid Synthesis in the Course of Experimental Inflammatory Colitis", Gastroenterology, 98:269-277 (1990).
Donowitz, "Arachidonic Acid Metabolites and Their Role in Inflammatory Bowel Disease, An Update Requiring Addition of a Pathway", Gastroenterology, 88:580-587.
Musch et al., "Stimulation of Colonic Secretion by Lipoxygenase Metabolites of Arachidonic Acid", Science, 217:1255-1256 (1982).
Palmer et al., "Chemokinetic Activity of Arachidonic Acid Lipoxygenase Products on Leuocytes of Different Species", Prostaglandins, 20:2:411-418 (1980).
Stenson et al., "Monohydroxyeicosatetraenoic Acids (HETEs) Induce Degranulation of Human Neutrophils", Journal of Immunology, 124:5:2100-2104 (1980).
Empey et al., "Fish Oil-Enriched Diet is Mucosal Protective Against Acetic Acid-Induced Colitis in Rats", Canad

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