Method of treating tumors using O-substituted fumagillol derivat

Details Method of treating tumors using O-substituted fumagillol derivat Method of treating tumors using O-substituted fumagillol derivat

1992-09-03

2000-01-25

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A01N 4320

Patent

active

060179546

ABSTRACT:
This invention relates to methods of using O-substituted fumagillol derivatives or salts thereof preferably, O-(N-chloroacetylcarbamoyl) fumagillol, O-(N-chloroacetylcarbamoyl)dihydrofumagillol or O-(N-chloracetylcarbamoyl)-6'b-hydroxyfumagillol, which have angiogenesis inhibitory activity, in the treatment and prevention of various diseases caused or advanced by abnormally hyperactive angiogenesis, especially various inflammatory diseases (rheumatism, psoriasis, etc.), diabetic retinopathy and cancer and other angiogenesis-dependent tumors, especially Kaposi's sarcoma, breast cancer, colon cancer.

REFERENCES:
patent: 4954496 (1990-09-01), Oku et al.
patent: 5698586 (1997-12-01), Kishimoto et al.
Derwent Printout from Dialog of the abstract corresponding to Japanese Kokai Tokkyo Koho No. 58-131978.
Derwent Printout from Dialog of the abstract corresponding to Japanese Kokai Tokkyo Koho No. 63-119500.
S. Taylor, et al., Nature, 297:307 (1982).
J. Folkman, et al., Science, 221:719 (1983).
D. Tarbell, et al., J. Am. Chem. Soc. 83:3096 (1961).
O. Mitsunobu, Synthesis, 1981, 1.
I. Sutherland (Ed.), "Comprehensive Organic Chemistry", vol. 2, pp. 4-11, Pergamon Press (1979).
Gimbrone, et al., J. National Cancer Institute, 52:413-419.
J. Ross, et al., J. Am. Chem. Soc., 78:4675 (1956).
Falk, et al., J. Immunol. Meth., 33:239-247 (1980).
Folkman, et al., Science, 230:1375 (1985).
Chemical Patent Index, Basic Abstracts Journal Section B, Week 8706, Abstract No. 87-040948/06, Abstract of JP-A-476/1987.
J. DiPaolo, et al., Antibiotics Annual, 1958-1959, pp. 541-546.
G. Ruecker, et al. Chemical Abstracts, 77:29f (1972).
The Merck Index, 11th Ed., (1989) pp. 670-671; Compound No. 4199--Fumagillin.
Salahuddin et al.; Science 242, 430 (1988).
T. Maione and R. Sharpe; "Development of angiogenesis inhibitors for clinical applications" TIPS 11, 457 (1990).
S. Nakamura et al.; Science 255, 1437 (1992) "Inhibition of Development of Kaposi's Sarcoma-Related Lesions by a Bacterial Cell Wall Complex".
T.J. Ryan, "Angiogenesis and Kaposi's Sarcoma"; Lymphology 21, 61 (1988).
J. Folkman, "What is the Evidence that Tumors Are Angiogenesis Dependent?" J. Natl. Cancer Inst., 82, 4 (1990).
AIDS Treatment News 135:1 (1991), J. James.
Chemical Abstracts, vol. 70, No. 9, Mar. 3rd, 1969, p. 206, abstract No. 36365g, Columbus, Ohio, US; M.M. Maevskii et al.
Chemical Abstracts, vol. 106, No. 21, May 25th, 1987, p. 706, abstract No. 176153y Columbus, Ohio, US; & JP-A-62 00 476 (Fujisawa Pharmaceutical Co., Ltd).
McOmie, Protective Groups in Organic Chemistry (1973), pp. 49-51.
Ingber et al., "Synthetic Analogues of Fumagillin . . . ", Nature 348, pp. 555-557 (1990).

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