Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1990-12-24
1993-09-07
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
435212, 435216, A61K 37547, C12N 968, C12N 970
Patent
active
052426882
ABSTRACT:
The present invention provides a method of treating thromboembolic disorders with the diglycosylated form of a tissue plasminogen activator derivative that lacks the Finger, EGF and Kringle I domains of the native tissue plasminogen activator molecule.
REFERENCES:
patent: 4751084 (1988-06-01), Feder et al.
patent: 4927630 (1990-05-01), Feder et al.
patent: 4935237 (1990-06-01), Higgins et al.
patent: 4970159 (1990-11-01), Dodd
patent: 5002887 (1991-03-01), Larsen
patent: 5037646 (1991-08-01), Higgins et al.
patent: 5089409 (1992-02-01), Howard et al.
Burck, et al., 1990, J. Biological Chemistry 265:5170-5177.
Jackson, et al., 1990, Circulation 82(3):930-940.
Wittmer and Howard, 1990 Biochemistry 29:4175-4180.
Parekh, et al., 1989, Biochemistry 28:7644:7662.
Parekh, et al., 1989, Biochemistry 28:7670-7679.
Wittwer, et al., 1989, Biochemistry 28:7662-7669.
Wu, et al., 1990, J. Cardiovascular Pharmacology 16:197-203.
Spellman, et al., 1989, J. Biological Chemistry 264(24):14100-14111.
Higgins and Bennett, 1990, Annu. Rev. Pharmacol. Toxicol. 30:91-121.
Pohl, et al., 1987, Eur. J. Biochem. 170:69-75.
Larsen, et al., 1989, Blood 73(7):1842-50.
Collen, et al., 1988, Blood 71(1):216-219.
Cambier, et al., 1988, J. of Cardiovascular Pharmacology 11:468-472.
Larsen, et al., 1988, J. of Biological Chemistry 263(2):1023-1029.
Hansen, et al., 1988, J. of Biological Chemistry 263(30):15713-15719.
Lau, et al., 1987, Bio/Technology 5:953-958.
Hotchkiss, et al., 1988, Thrombosis and Haemostasis 60(2):255-261.
Haigwood, et al., 1989, Protein Engineering 2(8):611-620.
Wilhelm, et al., 1990, Thrombosis and Haemostasis 63(3):464-471.
Johannessen et al., Thrombosis & Hemostasis 63:54-59, Feb. 19, 1990.
Urano et al., Proc. Natl. Acad. Sci. 86:2568-2571, Apr. 1989.
Van Zonneveld et al., J. Cell. Biochem 32:169-178, 1986.
Van Zonneveld et al., Proc. Natl. Acad. Sci. 83:4670-4674, Jul. 1986.
Van Zonneveld et al., J. Biol. Chem. 261:14214-14218, Oct. 25, 1986.
Gething et al., Embo Journal 7:2731-2740, 1988.
Browne et al., Fibrinolysis 3:207-214, 1989, as Abstracted in Biological Abstracts 89:AB-100, Ref. No. 21772, 1 Feb. 1990.
Burck Philip J.
Jackson Charles V.
Smith Gerald F.
Eli Lilly and Company
Plant Thomas G.
Walsh Stephen
Wax Robert A.
Whitaker Leroy
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