Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1994-07-21
1996-04-30
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
514284, 514176, 424 65, 424 69, A61K 3159, A61K 3144, A61K 734
Patent
active
055125557
ABSTRACT:
The instant invention involves methods of treating sweat related conditions with compounds that are 5.alpha.-reductase inhibitors. The 5.alpha.-reductase inhibitors may be administered alone or in combination with other active agents to treat conditions such as apocrine gland sweating, hyperhidrosis, and hydradenitis suppurativa.
REFERENCES:
patent: 4760071 (1988-07-01), Rasmusson et al.
Takayasu et al. "Activity of Testosterone 5alpha-reductase in Various Tissues of Human Skin" J. Invest. Dermatol., vol. 74, pp. 187-191 (1980).
Mortimer et al. "A double-blind controlled cross-over trial of cyrpoterone acetate in females with hidradenitis suppurativa" British J. Dermatology, vol. 115, pp. 263-268 (1986).
Sawers et al. "Control of hidradenitis suppurativa in women using combined antiandrogen(cyproterone acetate) and oestrogen therapy" British J. Dermatology, vol. 115, pp. 269-274 (1986).
Harris, et al. "Identification and selective inhibition of an isozyme of steroid 5 alpha reductase in human scalp" Proc. Natl. Acad. Sci., vol. 89, pp. 10787-10792 (1992).
Criares Theodore J.
Fitch Catherine D.
Merck & Co. , Inc.
Quagliato Carol S.
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