Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-07-03
1998-08-04
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 47, 424 45, 424 46, A61K 3170
Patent
active
057893918
ABSTRACT:
A method of promoting drainage of congested mucous secretions in the sinuses of a subject in need of such treatment is disclosed. The method comprises administering to the sinuses of the subject a uridine phosphate such as uridine 5'-triphosphate (UTP) or P.sup.1,P.sup.4 -di(uridine-5') tetraphosphate (U.sub.2 P.sub.4), an analog of UTP, or any other analog, in an amount effective to promote drainage of congested fluid in the sinuses by hydrating mucous secretions or by stimulating ciliary beat frequency in the sinuses. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include any liquid suspension (including nasal drops or spray), oral form (liquid or pill), aerosol inhalation, powder form, topical, injected, intra-operative instillation or suppository form.
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Benali et al. "Effect of extracellular ATP and UTP. . ." Medline 94183573, 1994.
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Drutz David
Jacobus Karla
Pendergast William
Rideout Janet
Siddiqi Suhaib
Bendrick John A.
Chang Ceila
Halluin Albert P.
Inspire Pharmaceuticals Inc.
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