Method of treating sinusitis with uridine triphosphates and rela

Details Method of treating sinusitis with uridine triphosphates and rela Method of treating sinusitis with uridine triphosphates and rela

1998-01-09

1999-10-26

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 47, 424 45, 424 46, A61K 3170

Patent

active

059729040

ABSTRACT:
A method of promoting drainage of congested mucous secretions in the sinuses of a subject in need of such treatment is disclosed. The method comprises administering to the sinuses of the subject a uridine phosphate such as uridine 5'-triphosphate (UTP) or P.sup.1,P.sup.4 -di(uridine-5') tetraphosphate (U.sub.2 P.sub.4), an analog of UTP, or any other analog, in an amount effective to promote drainage of congested fluid in the sinuses by hydrating mucous secretions or by stimulating ciliary beat frequency in the sinuses. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include any liquid suspension (including nasal drops or spray), oral form (liquid or pill), aerosol inhalation, powder form, topical, injected, intra-operative instillation or suppository form.

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