Method of treating sinusitis with uridine triphosphates and rela

Details Method of treating sinusitis with uridine triphosphates and rela Method of treating sinusitis with uridine triphosphates and rela

1998-01-09

1999-09-28

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424 45, A61K 3170

Patent

active

059588977

ABSTRACT:
A method of promoting drainage of congested mucous secretions in the sinuses of a subject in need of such treatment is disclosed. The method comprises administering to the sinuses of the subject a uridine phosphate such as uridine 5'-triphosphate (UTP) or P.sup.1,P.sup.4 -di(uridine-5') tetraphosphate (U.sub.2 P.sub.4), an analog of UTP, or any other analog, in an amount effective to promote drainage of congested fluid in the sinuses by hydrating mucous secretions or by stimulating ciliary beat frequency in the sinuses. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include any liquid suspension (including nasal drops or spray), oral form (liquid or pill), aerosol inhalation, powder form, topical, injected, intra-operative instillation or suppository form.

REFERENCES:
patent: 5292498 (1994-03-01), Boucher, Jr.
patent: 5420116 (1995-05-01), Puchelle et al.
patent: 5635160 (1997-06-01), Sutts et al.
Kintaka et al. "Analysis of small airway dysfunction in chronic sinusitis" Biol. Abst. 94:045,430, 1994.
Moss, A. and V. Parsons, 1985, National Center for Health Statistics, 1986, 66-7, DHHS Publication No. (PHS)89-1588.
Revonta, M. and A. Blokmanis, 1994, Can Fam Physician 40, 1969-72, 1975-76.
Kennedy, D. 1990, Otolaryngol. Head Neck Surg. 103:845-846.
Reuler, J., 1995, West J. Med.:40-8.
Boucher, R. et al., "Mechanisms and Therapeutic Actions of Uridine Triphosphates in the Lung." Adenosine and Adenine Nucleotides From Molecular Biology to Integrative Physiology., pp. 525-553 L. Belardinelli, et al., Alumwer Academic (1995).
Gheber, L. et al., 1995, J. Membrane Biol. 147: 83-93.
Gobran. L. et al., 1994, Am. J. Physiol. 267:L625-L633.
Cusack., N. and Hourani, S. "Biological Actions of Extracellular ATP" Annals N.Y Acad. Sci. pp. 525-553 (1990).
Hall and Khorana, 1954, J. Am. Chem. Soc. 76:5056.
Merck Index, Monograph No. 9795 (11.sup.th edition 1989).
Goody, R.S. and Eckstein, F. 1971, J. Am. Chem. Soc. 93:6252.
Kenner et al., 1954, J. Chem. Soc. 2288.
Rapaport, E. et al., 1981 Proc. Natl. Acad. Sci. USA 78(2): 838-842.
Ng, K. and Orgel, L.E. 1987, Nucleic Acids Research 15(8):3572-80.
Hoard D. and Ott D. 1965, J. Am. Chem Soc 87:1785-1788.
Yoshikawa, M. et al., 1967 Tetrahedron Lett. 5065-5068 and idem Bull. Chem. Soc. (Jpn) 42, 3505-3508 1969.
Moffatt, J. and Khorana H. 1961, J Am. Chem. Soc. 649-659.
Fischer, B. et al., 1993, J. Med. Chem. 36:3937-3946.
Kotchtkov, N. et al., 1991 Tetrahedron Lett 1993.
Barrio, J. et al., 1972, Biochem. Biophys. Res. Commun. 46:397.
Secrist, J. et al., 1972, Biochemistry 11:3499.
Bierndt, J. et al., 1978, Nucleic Acids Res. 5:789.
Koyasuga-Mikado, K. et al., 1980, Chem. Pharm. Bull. (Tokyo) 28:932.
Ludwig, J. and Eckstein, F. 1989, J. Org. Chem. 54, 631-635.
Blackburn, G. et al., 1984, J. Chem. Soc. Perkin Trans. 1:1119:1125.
Eckstein,F. and Goody, R. 1963, Biochemistry 15:1685.
Myers, T. et al. 1963, J. Am. Chem. Soc. 85:3292-3295.
Benali et al., 1994 "Effects of Extracellular ATP and UTP . . . " Medline 94183573.
Zeiger 1992 "Prospects for ancillary treatment of sinusitis . . . " Medline 92407246.
Scrip 1995 2067 Inspire Pharmaceuticals focuses on chronic obstructive. . ..
Scrip 1995 2151 US orphan status for Inspire's. . ..

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