Method of treating sickle cell anemia

Details Method of treating sickle cell anemia Method of treating sickle cell anemia

1983-11-21

1987-11-03

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514571, 514815, A61K 31235, A61K 3119

Patent

active

047044020

ABSTRACT:
A method of treating a person for sickle cell anemia including administering to the person a therapeutically effective dosage of the compound ##STR1## wherein at least one R=Cl, BR, CH.sub.3 or OCH.sub.3 and each other R=H, R'=H or CH.sub.3 and n=1, 2, 3, 4 or 5. The compound is preferably selected from the group consisting of clofibrate, clofibric acid, p-chlorophenoxyacetic acid and phenoxyacetic acid. It is preferably administered in solid dosage form and may advantageously be employed in prophylactic treatment to resist sickle cell crises.

REFERENCES:
patent: 3262850 (1966-07-01), Jones et al.
patent: 4062974 (1977-12-01), Coirault
Goodman et al.-the Pharmacological Basis or Therapeutics, 6th Ed, pp. 68, 91, 694.
AMA Drug Evaluations (4th Ed. 1980) pp. N-34-N-36.
National Library of Medicine, "Sickle Cell Anemia" Special Literature Search, Jan. 1970-Jun. 1974.
National Library of Medicine "Sickle Cell Anemia" Special Literature Search, Jul. 1974-Mar. 1978.
"Hemoglobin and the Sickling Cell" by Larry Varner Pitt Capsule, pp. 4-18.

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