Method of treating sick sinus syndrome with levosimendan

Details Method of treating sick sinus syndrome with levosimendan Method of treating sick sinus syndrome with levosimendan

2005-06-28

2005-06-28

Page, Thurman K. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

C424S449000, C424S464000, C514S772600

Reexamination Certificate

active

06911209

ABSTRACT:
Levosimendan, or (−)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile, which has been previously suggested for the treatment of congestive heart failure is useful in the treatment of sick sinus syndrome and/or sinoatrial conduction disorders.

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patent: WO 98/18475 (1998-05-01), None
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Du Toit et al., ‘Levosimendan: Effects of a Calcium Sensitizer on Function and Arrhythmias and Cyclic Nucleotide Levels during Ischemia/Reperfusion in the Langendorff-Perfused Guinea Pig Heart’, The Journal of Pharmacology and Experimental Therapeutics, vol. 290, pp. 505-514, 1999.

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