Method of treating septic shock using thymosin-.alpha. 1

Details Method of treating septic shock using thymosin-.alpha. 1 Method of treating septic shock using thymosin-.alpha. 1

1994-06-10

1996-12-17

Knode, Marian C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 530301, A61K 3800, C07K 500, C07K 700, C07K 1700

Patent

active

055853528

ABSTRACT:
A method of reducing toxicity of endotoxin in a mammal including the administration of an endotoxin-reducing effective amount of T.alpha..sub.1 to the mammal.

REFERENCES:
patent: 4079127 (1978-03-01), Goldstein et al.
patent: 4297276 (1981-10-01), Golstein et al.
patent: 5055447 (1991-10-01), Palladino et al.
Cross et al, Infection and Immunity vol. 61 p. 2741 (1993).
Fitzer-Schiller, Washington Post, Jan. 19, 1993 p. D3.
Biotechnology Newswatch, Aug. 1, 1994 pp. 1 and 4.
Ishitsuka et al., "Protective Activity of Thymosin Against Opportunistic Infections in Animal Models," Cancer Immunology Immunotherapy, 14:3, pp. 145-150 (Mar. 1983).
Sanders et al., "Thymosin .beta..sub.4 (Fx peptide) is a potent regulator of actin polymerization in living cells", Proc. Natl. Acad. Sci. USA, 89:10, pp. 4678-4682, May 15, 1992.
Ashkenazi et al., "Protection against endotoxic shock by a tumor recrosis factor receptor immunoadhesin", Proc. Natl. Acad. Sci. USA, 88:23, pp. 10535-10539, Dec. 1, 1991.
Watt et al., "Alterations in plasma levels and complexing of Gc (vitamin D-binding protein) in rats with endotoxic shock", Biological Abstracts, 88:7, Abstract No. 75029, 1989 (Circ Shock, 28:3, pp. 279-292, 1989).
Sawada, Shuzo, et al., "Protection against Infection with Pseudomonas aeruginosa by Passive Transfer of Monoclonal Antibodies to Lipopolysaccharides and Outer Membrane Proteins," J. of Inf. Diseases, 150:4 (Oct. 1984) p. 570.
Low, Teresa L. K., et al., "Thymosins: structure, function and therapeutic applications," Thymus 6, pp. 27 et seq. (1984).
Teng, Nelson N. H., et al., "Protection against Gram-negative bacteremia and endotoxemia with human monoclonal IgM antibodies," Proc. Natl. Acad. Sci., vol. 82, pp. 1790-1794 (Mar. 1985).
Webster's Third New International Dictionary, p. 1798 (1986).
Dorland's Illustrated Medical Dictionary, 26th ed., p. 1026.
Baumgartner, J. D., et al., "Asociation between Protective Efficacy of Anti-Lipopolysaccharide (LPS) Antibodies and Suppression of LPS-Induced Tumor Necrosis Facto .alpha. and Interleukin 6," J. Exp. Med., 171:889-896 (Mar. 1990).
Safer, Daniel, et al., "Thymosin .beta..sub.4 and Fx, an Actin-sequestering Peptide, Are Indistinguishable," J. of Biol. Chem., vol. 266, No. 7, pp. 4029-4032 (Mar. 1991).
Lee, William M., et al., "The Extracellular Actin-Scavenger System and Actin Toxicity," New England J. of Med., vol. 326, No. 20, pp. 1335-1341 (May. 14, 1992).

Affiliated with

Also associated with

Rating

Method of treating septic shock using thymosin-.alpha. 1 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of treating septic shock using thymosin-.alpha. 1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating septic shock using thymosin-.alpha. 1 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1991313