Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1997-04-29
2000-03-28
Mertz, Prema
Drug, bio-affecting and body treating compositions
Lymphokine
514 2, 514 8, 514 12, 514885, A61K 3819
Patent
active
06042821&
ABSTRACT:
The invention relates to the method of preventing and treating sepsis using chemokines selected from mature or modified KC [SEQ ID NO: 1], gro.alpha. [SEQ ID NO:2], gro.beta. [SEQ ID NO: 3] or gro.gamma. [SEQ ID NO: 4] or multimers thereof, alone or in conjunction with an anti-infective agent. This invention also relates to a new gro.beta. dimer chemokine.
REFERENCES:
Bowie et al. Science vol. 247, pp. 1306-1310, 1990.
G. Arturson, "Neutrophil granulocyte functions in severely burned patients", (1985), Burns, vol. 11, pp. 309-314.
Jansen, et al., "Monocyte Chemotactic Protein 1 is Released during Lethal and Sublethal Bacteremia in Baboons", (1995), The Journal of Infectious Diseases, vol. 171, pp. 1640-1642.
Bossink, et al., "Plasma Levels of the Chemokines Monocyte Chemotactic Proteins-1 and -2 Are Elevated in Human Sepsis", (1995), Blood, vol. 86, No. 10, pp. 3841-3847.
K.E. Driscoll, "Macrophage Inflammatory Proteins: Biology and Role in Pulmonary Inflammation", (1994), Experimental Lung Research, vol. 20, pp. 473-490.
Burgmann, et al., "Serum Concentrations of MIP-1 .alpha. and Interleukin-8 in Patients Suffering from Acute Plasmodium falciparum Malaria", (1995), Clinical Immunology and Immunopathology, vol. 76, No. 1, pp. 32-36.
DeMarsh Peter Lawrence
Johanson Kyung Oh
Hall Linda E.
Kinzig Charles M.
Mertz Prema
SmithKline Beecham Corporation
Venetianger Stephen A.
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