Method of treating retained pulmonary secretions

Details Method of treating retained pulmonary secretions Method of treating retained pulmonary secretions

1995-05-02

1997-11-04

Bawa, Raj

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424 46, 514924, A61K 912

Patent

active

056836759

ABSTRACT:
A method of facilitating the clearance of retained pulmonary secretions in a subject using lantibiotics is disclosed. The method comprises administering to the lungs of the subject an effective amount of a lantibiotic. The lantibiotic is preferably administered by topically applying it to the respiratory epithelia, such as by generating an aerosol thereof which is then inhaled by the subject. A preferred lantibiotic for carrying out the present invention is duramycin. The method may be used in treating disorders such as cystic fibrosis, chronic bronchitis, and asthma. Also disclosed is a method of combatting tuberculosis comprising administering a lantibiotic to a subject in need of such treatment.

REFERENCES:
patent: 5135910 (1992-08-01), Blackburn et al.
Mattick, A.T.R., et al. (1947). Lancet, vol. ii, pp. 5-7.
Berkow, R. (1992). The Merck Manual, 16th. edition. Merck & Co., Inc., pp. 139-146; pp. 2045-2047.

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