Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-08-31
1998-03-03
Tsano, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 8, 514 21, A61K 3800, A61K 3828, A61K 3827
Patent
active
057234418
ABSTRACT:
Treatment with IGF/IGFBP-3 complex increases renal tubular mass and potentiates and/or stimulates kidney function in subjects suffering from acute and chronic renal failure or insufficiency resulting from such disorders as glomerulonephritis, glomerulosclerosis, interstitial nephritis, acute tubular necrosis due to ischemia and drug-induced toxicity, diabetic and autoimmune nephropathies and renal dysfunction due to acute and chronic rejection episodes in post-transplantation patients.
REFERENCES:
patent: 3773919 (1973-11-01), Boswell et al.
patent: 5106832 (1992-04-01), Froesch et al.
patent: 5273961 (1993-12-01), Clark
Guler et al., "Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats," (1988) Proc. Nat'l Acad. Sci. USA 85:488-4893.
Rabkin et al., "Insulin-like growth factor-1 (IGF-1) enhances recovery from acute renal failure (ARF) induced by ischemia" J. Am. Soc. Nephrol.(1992) 3:713.
Andersson et al., "IGF-1 immunoreactivity is expressed by regenerating renal tubular cells after ischaemic injury in the rat" Acta Physiologica Scandinavica(1988) 132:453-457.
Sommer et al., in "Modern Concepts of Insulin like Growth Factors" pub 1991, Elsevier Pub. Co. pp. 715-728.
Blum et al., "Plasma IGFBP-3 levels as clinical indicators" Modern Concepts in Insulin-Like Growth Factors (1991) Spencer, E. M., ed., Elsevier, New York, pp. 381-393.
Rinderknecht et al., "Polypeptides with nonsuppressible insulin-like and cell-growth promoting activities in human serum: Isolation, chemical characterization, and some biological properties of forms I and II" Proc. Natl. Acad. Sci. USA (1976) 73(7):2365-2369.
Baxter et al., "Growth hormone-dependent insulin-like growth (IGF) binding protein from human plasma differs from other human IGF binding proteins" Biochem. Biophys. Res. Comm. (1986) 139(3):1256-1261.
Sommer et al., "Molecular genetics and actions of recombinant insulin-like growth factor binding protein-3" Modern Concepts In Insulin-Like Growth Factors (1991) Spencer, E.M., Elsevier, New York, pp. 715-728.
Miller et al., "Effects of growth hormone and IGF-I on renal function in rats with normal and reduced renal mass" Am. J. Physiol. (1990) 259:F747-F751.
Miller et al., "Insulin-like growth factor I accelerates recovery from ischemic acute tubular necrosis in the rat" Proc. Natl. Acad. Sci. USA (1992) 89:11876-11880.
Ritz et al., "Influence of growth hormone and insulin-like growth factor-I on kidney function and kidney growth" Pediatr. Nephrol. (1991)5:509-512.
Blum et al., "Growth hormone resistance and inhibition of somatomedin activity by excess of insulin-like growth factor binding protein in uraemia" Pediatr. Nephrol. (1991) 5:539-544.
Mulroney et al., "Altered expression of insulin-like growth factor-I (IGF-I) and IGF receptor genes after unilateral nephrectomy in immature rats" Endocrinol. (1992) 130(1):249-256.
Flyvbjerg et al., "Kidney IGF-I accumulation occurs in four different conditions with rapid initial kidney growth in rats" Modern Concepts In Insulin-Like Growth Factors (1991) Spencer, E.M., ed., Elsevier, New York, pp. 207-217.
Guyda, H. "Concepts of IGF physiology" Modern Concepts In Insulin-Like Growth Factors (1991) Spencer, E.M., ed., Elsevier, New York, pp. 99-109.
Chin et al., "Renal growth horome receptor gene expression: relationship to renal insulin-like growth factor system" Endocrinol. (1992) 131(6):3061-3066.
Bach et al., "Diabetes-related renal growth and IGF-I accumulation in castrated rats" Diabetes Res. Clin. Pract. (1991) 14:15-20.
Martin et al., "IGF-I and its variant, des-(1-3)IGF-I, enhance growth in rats with reduced renal mass" Am. J. Physiol. (1991) 261:F626-F633.
Guler et al., "Effects of recombinant insulin-growth factor I on insulin secretion and renal function in normal human subjects" Proc. Natl. Acad. Sci. USA(1989) 86:2868-2872.
Guler et al., "Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults" N. Engl. J. Med. (1987) 317(3):137-140.
Sidmon et al., "Controlled release of macromolecules and pharmaceuticals from synthetic polypeptides based on glutamic acid" Biopolymers (1983) 22(1):547-556.
Langer et al., "Biocompatibility of polymeric delivery systems for macromolecules" J. Biomed. Res. (1981) 15:267-277.
Hirschberg et al., "The effects of insulin-like growth factor I on renal hemodynamics" Modern Concepts In Insulin-Like Growth Factors (1991) Spencer, E. M., ed., Elsevier, New York, pp. 199-206.
Ho et al, "The antinatriuretic action of biosynthetic human growth hormone in man involves activation of the renin-angiotensin system" Metabolism (1990) 39(2):133-137.
Kanda et al., "Anti-epidermal growth factor antibody inhibits compensatory renal hyperplasia but not hypertrophy after unilateral nephrectomy in mice" Biochem. Biophys. Res. Comm. (1992) 187(2):1015-1021.
Mehls et al., "Growth hormone in renal transplantation--the mode of action, animal studies, and clinical use" J. Am. Soc. Nephrol. (1992) 2:S284-S289.
Mehls et al., "Growth hormone and insulin-like growth factor in chronic renal failure-pathophysiology and rationale for growth hormone treatment" Acta. Paediatr. Scand. (Suppl). (1990) 370:28-34.
Rogers et al., "Growth hormone stimulates IGF I gene expression in isolated rat renal collecting duct " Am. Physiol. Soc. (1990) pp. F474-F479.
Higley Howard R.
Maack Christopher A.
Celtrix Pharmaceuticals Inc.
Touzeau P. L.
Tsano Cecilia J.
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