Method of treating renal cell carcinoma using activated mononucl

Details Method of treating renal cell carcinoma using activated mononucl Method of treating renal cell carcinoma using activated mononucl

1991-08-19

1993-03-09

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

424 88, 424 93R, 424534, 514 2, 514339, 514482, A61K 4505, A61K 3900, A01N 6300, A01N 4324

Patent

active

051925370

ABSTRACT:
Immunoreactive cells sensitized for an antigenic marker associated with a malignant tumor are prepared in vitro by collecting the tumor patient's own mononuclear cells, depleting suppressor T-cells, suspending the mononuclear cells with serum, preferably autologous, and culturing the cells under conditions to activate and immunize the patient's mononuclear cells against the patient's tumor. Methods of treatment and immunized cells in pharmaceutical presentations are described.

REFERENCES:
patent: 4404280 (1983-09-01), Gillis
patent: 4444887 (1984-04-01), Hoffman
patent: 4690915 (1987-09-01), Rosenberg
patent: 4716111 (1987-12-01), Osband et al.
Osband et al "Successful Tumor . . . " The Lancet Mar. 21, 1981, vol. 1:636-638.
Palacios "Cimetidine . . . " Immunol. Lett. 3(1):33-37 (1981).
Berken "Case for Adoptive Immunotherapy in Cancer" Lancet Nov. 27, 1982 pp. 1190-1192.
Strausser et al. J Imm vol. 127 pp. 266-271 1981 "Lysis of human solid tumors by autolayer cells sensitized in vitro to alloantigens".
Lotze et al. Cancer Res vol. 41 Nov. 1981 pp. 4420-4426 "Lysis of fresh and cultured autolayer tumor by human lymphocytes cultured in T cell growth facter".
Palacios et al. Chem Abst 1981 vol. 95(5) No. 35349j "Cimetidine abrogaates suppressor T cell function in vitro".
Mazumder et al. Chem Abst vol. 96(23) No. 197,727d "Lysis of fresh human solid tumors by autolayer lymphocyles activated in vitro with lectins".
Lotze et al. Biol. Abst. 73:84574 (1981).
Hoffman Proc. Natl. Acad. Sci. USA vol. 77, No. 2, pp. 1139-1143, Feb. 1980.
Oppenheim et al. Basic & Clinical Immunology pp. 86-90, 1984.
Frenster The Lancet pp. 979-980, Nov. 2, 1968.
Suciu-Foca et al. Chem. Abst. 80(15):80827q 1972.

Affiliated with

Also associated with

Rating

Method of treating renal cell carcinoma using activated mononucl does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of treating renal cell carcinoma using activated mononucl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating renal cell carcinoma using activated mononucl will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-209601