Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1993-10-28
1997-07-15
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 276, A61K 3170
Patent
active
056483414
ABSTRACT:
The described invention relates to a method of treatment of a pulmonary inflammatory reaction brought about by e.g. bacteraemia, physical trauma or viral infection, with activation of polymorphonuclear white blood cells, said method comprising continuous intravenous infusion of adenosine at a rate effective for such treatment, preferably 2 to 50 .mu.g/ml/min, more preferably 5-20 .mu.g/kg/min in a central vein.
REFERENCES:
patent: 5104859 (1992-04-01), Sollevi
patent: 5231086 (1993-07-01), Sollevi
Drury et al., "The Physiological Activity of Adenine Compounds with Especial Reference to Their Action Upon the Mammalian Heart," J. Physiology (Cambridge), 68, 213-237 (1929).
Kassell et al., "Cerebral and Systemic Circulatory Effects of Arterial Hypotension Induced by Adenosine," Neurosurgery, 58(1), 69-76 (1983).
Fukunaga et al.(I), "ATP-Induced Hypotensive Anesthesia During Surgery," Anesthesiology, 57(3), A65 (1982).
Fukunaga et al.(II), "Hypotensive Effects of Adenosine and Adenosine Triphosphate Compared with Sodium Nitroprusside," Anesthesia and Analgesia, 61(3), 273-278 (1982).
Kikugawa et al., "Platelet Aggregation Inhibitors. 4. N.sup.6 -Substituted Adenosines," J. Medicinal Chem., 16(4), 358-364 (1973).
Masters et al., "Platelet Anti-aggregating and Hemodynamic Effects of Adenosine and Prostaglandin E.sub.1 ", Thorac. Cardiovasc. Surgeon, 30, 14-20 (1982).
Belardinelli et al, "The cardiac effect of adenosine," Prog. Cardio Dis 1989; 32(1): 73-97.
Ward et al, "Functional consequences of interactions between human neutrophils and ATP, ATPS, and Adenosine," Ann NY Acad Sci 1990; 603: 108-19.
Cronstein et al, "Engagement of Adenosine Receptors Inhibits Hydrogen Peroxide (H.sub.2 O.sub.2) . . . ," Clinical Immunology and Immunopathology 1987; 42: 76-85.
Cronstein et al, "Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells," J Clin Invest 1986; 78: 760-770.
Sollevi, A., "Clinical studies on the effect of adenosine," Elsevier Sci Publ BV. Role of adenosine nucleotides in the biological system. Shoichi Imai, Mikio Nakazawa eds. 1991; pp. 525-537.
Kaminski et al, "Actions of Adenosine on Nitro Blue Tetrazolium Deposition . . . ," Circulation Research 1990; 66(6): 1713-1719.
Ely et al, "Protective effects of adenosine in myocardial ischemia," Circulation 1992; 85(3): 893-904.
Chrisots J. Pitarys II et al, "Reduction of myocardial reperfusion injury by intravenous adenosine administered during the early reperfusion period," Circulation 1991; 83: 237-247.
Tadokoro et al, "Profound infarct size reduction with retrograde coronary venous administration of adenosine," Circulation. Suppl. Nov. 1990.
Boehm et al, "Adenosine cardioplegia: Reducing reperfusion injury of the ischaemic myocardium," Eur J Cardio-thorac Surg 1991; 5: 542-545.
Norton et al, "The effect of intravenous infusions of selective adenosine A.sub.1 -receptor and A.sub.2 -receptor agonists on myocardial reperfusion injury," American Heart J 1992; 123: 332-338.
Karasawa et al, "Effect of adenosine, and adenosine A.sub.1 -antagonist, and their combination in splanchnic occlusion shock in rats," Circulatory Shock 1992; 36: 154-161.
Bileviciute et al, "Neurokinin A is released by capsaicine from rat knee joint afferents if preceded by adenosine or morphine," 7th World Congress on Pain, Paris, Aug. 1993.
Broe et al, "Aspiration pneumonia: Treatment with pulmonary vasodilators," Surgery 1983; 94: 95-99.
Gabridge et al, "Role of Adenine in the Pathogenesis of Mycoplasma pneumoniae infections of Tracheal Epithelium," Med. Microbiol. Immunol. 1978; 165: 43-45.
Bradley et al, "Adenosine prevents phorbol ester injury in rabbit lungs: role of leukotrienes and TNF," Journal of Applied Physiology 1991; 71: 1949-1955.
Pelleg et al, "The Pharmacology of Adenosine," Pharmacotherapy 1990; 10(3): 154-174.
Crane L. Eric
Item Development AB
Kight John
LandOfFree
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