Method of treating psychosis and/or hyperactivity

Details Method of treating psychosis and/or hyperactivity Method of treating psychosis and/or hyperactivity

1997-10-17

2000-01-11

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

A61K 3800

Patent

active

060136219

ABSTRACT:
The present invention discloses the bidirectional regulation of DARPP-32 phosphorylation by dopamine and dopamine D1 and D2 receptors. This disclosure leads to new methodology in the treatment of schizophrenia and related disorders. In addition, the present invention provides methods for identifying agents that can be used in such treatment.

REFERENCES:
patent: 5777195 (1998-07-01), Fienberg et al.
Aitkin A. et al. (1982), Eur. J. Biochem., 126:235-246.
Aperia A. et al. (1991), Proc. Natl. Acad. Sci. USA, 88:2798-2801.
Beaurepaire et al. (1995) 121:323-7.
Begley, D.J. et al. (1990), J. of Neurochem., 55:1222-1230.
Boer et al. (1995) Psychopharmcology 121:317-22.
Borlongan et al. (1996) Surg. Neurol. 46:384-8.
Braff, D.L., and Geyer, M.A. (1990), Arch Gen Psychiatry, 47:181-188.
Cooper DM et al. (1995), Nature, 374:421-424.
Dawson, T.M. (1996) Annals of Neurology 40:559-60.
Dawson et al., (1993), Proc. Natl. Acad. Sci., 90:9808-9812.
Dolan et al. (1995) Nature 378:180-2.
Dragunow M. et al. (1990), Neuroscience, 37:287-94.
Fitzgerald LW et al.(1995), J. Neurosci., 15:2453-61.
Gerfen CR et al (1990), Science, 250: 1429-1432.
Ghasemzadeh MB et al.(1996), Molec Pharmacol. ,49:852-859.
Halpain S et al (1990), Nature, 343:369-372.
Hemmings Jr Hc et al(1984), Nature, 310: 503-505.
Hemmings Jr HC et al.(1986), J .Neurosci., 6: 1469-1481.
Karlsson P et al. (1995), Psychopharmacology, 121: 309-16.
King MM et al. (1984), J. Biol. Chem .,259:8080-8083.
Levine et al. (1994) Lancet 344:59-60.
Matsuura et al. (1996) Brain Res. 733:101-4.
Nestler, E.J. (1997) Nature 385:578-9.
Okubo et al. (1997) Nature 385:634.
Onali P et al. (1985), Mol. Pharmacol., 28: 138-145.
Ouimet CC et al. (1984), J. Neurosci .,4: 111-124.
Polli JW and Kincaid RL (1994), J. Neurosci., 14: 1251-1261.
Seeman P and Van Tol HH (1994), Trends in Pharmacol. Sci., 15:264-70.
Sibley et al. (1992), Trends in Pharmacol., Sci., 13: 61-69.
Sipes T. A. and Geyer M.A. (1995), Psychopharmacology, 117:41-48.
Snyder GL et al. (1996), Soc. Neurosci. Abst., 22: 380 (Abst. 153.11).
Snyder et al. (1995) Nature Med. 1:32-6.
Snyder GL et al.(1992), J. Neurosci ., 12: 3071-3083.
Steiner et al. (1997) Nature Med. 3:421-8.
Stoof JC and Kebabian JW (1981), Nature, 294: 366-8.
Surmeier DJ et al.(1994) , Neuron , 14:385-397.
Surmeier DJ et al. (1992), Proc. Natl. Acad. Sci., USA, 89: 10178-10182.
Surmeier DJ et al. (1996), J. Neurosci., 16: 6579-91.
Thastrup O et al.(1990), Proc. Natl. Acad. Sci., USA 87: 2466-70.
Walaas SI et al. (1983), Nature, 301: 69-71.
Walaas SI and Greengard P (1984), J. Neurosci, 4 :84-98.
Wera et al. (1994) Med. Hypotheses 43:132-4.
Nishi et al., 1997, J. Neuroscience, 17:8147-55.
Reynolds, 1996, Royal Pharmaceutical Society, 672-73.
Varty et al., 1995, Psychopharmacology, 122:15-26.
Wan et al., 1993, Psychopharmacology, 113:103-9.
Albert et al., 1998, Society for Neuroscience Abstract, 24:754.
Guitart et al., 1992, J Neurochem, 59:1164-7.
Gong et al., 1996, Brain Research, 741:95-102.
Grebb, 1990, Nakazawa ed.: Raniguchi Symosia on Brain Science, NO 14. Bop;pgica; Basis of Schizophrenic Disorders, 14th International Symposium Datata, 80-2.
Wan et al., 1996, Neuropsychoharmacology, 14:165-74.
Mermelstein et al., 1996, Society for Neuroscience Abstract, 22:2028.
Tanaka et al. Int. Congr. Ser., 1116, 57-65 (Abstract), 1996.

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