Method of treating psychoses in human beings with the atypical n

Details Method of treating psychoses in human beings with the atypical n Method of treating psychoses in human beings with the atypical n

1990-04-11

1992-05-12

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31445

Patent

active

051128381

ABSTRACT:
A method of treating psychoses in human beings with the atypical neuroleptic 5-chloro-1-(4-fluorophenyl)-3-(1-(2-(2-imidazolidinon-1-yl) ethyl-4-piperidyl)-1H-indole, having the formula: ##STR1## or a pharmaceutically-acceptable salt thereof, thereby to selectively block dopamine neurones in the ventral tegmental area of the brain, substantially without blocking dopamine neurones in the substantia nigra pars compacta, and therefore without the usual extrapyramidal side effects of common neuroleptics, is disclosed.

REFERENCES:
patent: 4359468 (1982-11-01), Freter et al.
patent: 4710500 (1987-12-01), Perregaard
patent: 4742057 (1988-05-01), Ueda et al.
Skarsfeldt, T et al., Eur. J. Pharmacol. 182:613-14 (1990).
"Current CNS Patents", vol. 1, No. 10, for Dec. 1990--eight (8) pages including especially pp. 653 and 654 relating to Sertindole, a highly selective atypical neuroleptic.
"The Positive-Negative Dimension in Schizophrenia: Its Validity and Sifnificance", Psychiatric Developments 2, pp. 79-103; Stanley R. Kay and Lewis A. Opler; Oxford University Press (1987).

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