Method of treating prolactin-related disorders

Details Method of treating prolactin-related disorders Method of treating prolactin-related disorders

1984-08-24

1987-04-14

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514899, A61K 3113

Patent

active

046579320

ABSTRACT:
A method of decreasing the concentration of prolactin in an animal, which comprises administering to the animal a prolactin-decreasing amount of cysteamine.

REFERENCES:
Szabo et al. Endocrinology, vol. 109, #6, p. 225 (1981).
Horner et al. Life Sciences, vol. 29, p. 2437 (1981).
Prescott, et al. Lancet, 2:109-113 (1976).
Yudkoff et al. New England J. of Medicine, 304:141-145 (1981).
Williams, Textbook of Endocrinology, 5th ed. pp. 46-49, 75-77 (1974).
Thoerne et al. J. of Clinical Investigation, vol. 58, pp. 180-189, Jul. 1976.
Lorenson et al. Endocrinology, vol. 110, No. 4, pp. 1164-1172 (Apr. 1981).
Simpkins, J. W. et al., Endocrinology, 112 No. 5, pp. 1889-1891 (1983),entitled "Cysteamine Depletes Prolactin in Young and Old Hyperprolactinemic Rats".
Millard, J. W. et al., Endocrinology, 113, No. 6, pp. 2161-2167, (1983), entitled "Cysteamine Induced Depletion of Both Immunological and Biological Prolactin Activity in the Anterior Pituitary and Blood of the Rat".
Harrision's Principles of Internal Medicine, 10th Edition, 1983, Index, pp. 58, 600, 601, 722, subtitled "Hyperprolactinemia", p. 440, and p. 722.
Millard, W. J. et al., Science, vol. 217, pp. 452-454, (Jul. 1982), entitled "Cysteamine: A Potent and Specific Depletor of Pituitary Prolactin".
Millard, W. J. et al., Abstract 326, Annual Meeting of Endocrine Society held San Antonio Jan. 1983, entitled "Cysteamine-induced Depletion of Both Immunological and Biological Prolactin Activity in the Anterior Pituitary and Blood of the Rat".
Parsons, J. A. et al., Abstract 1182, Annual Meeting of Endocrine Society held San Antonio Jan. 1983, entitled "Effect of Cysteamine on Pituitary and Serum Prolactin Measured by Nb 2 Node Rat Lymphoma Cell Bioassay".
Neuroendocrinology, vol. 38, pp. 182-188, (1984), Saunders et al, "Cysteamine Acts Immediately to Inhibit Prolactin Release and Induce Cellular Changes in Estradiol-Primed Male Rats".
Parsons et al., Endocrinology 114:1812-1817 (1984), "Effects of Cysteamine on Pituitary, MtTW.sub.15 Tumor, and Serum Prolactin Levels Measured by Rat Lymphoma Cell Bioassay and Radioimmunoassay".
Fluckiger et al., Effects of ergot Alkaloids on the Hypothalmic-Pituitary Axis", Postgraduate Medical Journal, 1976, 52 (Suppl. 1), 57-61.
The Merck Index, 1976, pp. App-1.

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