Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1988-06-14
1990-03-06
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 19, A61K 3702
Patent
active
049066145
ABSTRACT:
A method of preventing or treating posttraumatic nervous injuries by administering a compound of the formula: ##STR1## wherein R.sub.1 is hydrogen, a lower alkyl group, cyclohexyl or benzyl; Z is one of the groups ##STR2## if Z is a group (a), R.sub.2 and R.sub.3 together represent an additional bond between the carbon atoms bearing them, or if Z represents a group (b), R.sub.2 is hydrogen; R.sub.4 is hydrogen or lower alkyl; R.sub.5 is hydrogen, lower alkyl or phenyl, and R.sub.6 is hydrogen or methyl. Hydrates or pharmaceutically acceptable acid addition salts may also be used in the method. Pharmaceutical compositions used in this method containing such compounds in a prophylactically or therapeutically effective amount may be administered by infusion, injection, orally, perorally, rectally, percutaneously or other route.
REFERENCES:
patent: 4608365 (1986-08-01), Engel
Griffiths, "Thyrotrophin Releasing Hormone: Endocrine and Central Effects", Psychoneuroendocrinology, vol., 10, #3, pp. 225-235 (1985).
McIntosh et al., "Beneficial Effect of the TRH Analog CG-3703 on Hypertension and Neurological Deficit Caused by Traumatic Brain Injury in Rats", Cir. Shock, vol. 21, p. 376 (1987).
Faden et al., Neuropeptides in Spinal Cord Injury: Comparative Experimental Models, Peptides, vol. 4, pp. 631-634 (1983).
Webster et al., "Antinociceptive Effects of Thyrotrophin-Releasing Hormone and Its Analogues in the Rat Periaqueductal Grey Region", Neuroscience Letters, vol. 42, No. 1, pp. 67-70 (1983).
Faden et al., "Thyrotropin-Releasing Hormone Improves Neurologic Recovery After Spinal Trauma in Cats", 305 N. Eng. J. Med., 1063 (1981).
Faden et al., "Comparison of Thyrotropin-Releasing Hormone (TRH), Naloxone, and Dexamethasone Treatments in Experimental Spinal Injury", 83 Neurology 673 (1983).
Faden et al., "Opiate Antagonists and Thyrotropin-Releasing Hormone", 252 J. Am. Med. Assn. 1452 (1984).
Metcalf, "Regulatory Peptides as a Source of New Drugs-The Clinical Prospects for Analogues of TRH Which are Resistant to Metabolic Degradation", 4 Brain Research Reviews 389 (1982).
Faden, "Opiate Antagonists and Thyrotropin-Releasing Hormone", 252 J. Am. Med. Assn. 1177 (1984).
Faden et al., "Effects of TRH Analogs on Neurologic Recovery After Experimental Spinal Trauma", 35 Neurology 1331, (1985).
Hoppe et al., "Safety and Endocrinological Effects of TRH-Analog CG 3509 After Single and Multiple Administration in Normal Volunteers", Thyrotropin-Releasing Hormone 374 (1983).
Griffith et al., "Inactivation of Some TRH Analogues by Rat Brain: Product Indentification by HPLC", Thyrotropin-Releasing Hormone, 368 (1983).
Benkert et al., "Clinical and Endocrinological Effects of the TRH Analogue CG 3509 in Depression", Thyrotropin-Releasing Hormone 353 (1983).
Flohe et al., "Biological Effects of Degradation-Stabilized TRH Analogues", Thyrotropin-Releasing Hormone 327 (1983).
Metcalf, "The Neuropharmacology of TRH Analogues", Thyrotropin-Releasing Hormone 315 (1983).
Heal et al., "Actions of TRH and its Analogues on the Mesolimbic Dopamine System", Thyrotropin-Releasing Hormone 271 (1983).
Bennett et al., "TRH and Catecholamine Neurotransmitter Release in the Central Nervous System", Thyrotropin-Releasing Hormone 253 (1983).
Webster et al., "Induction of Wet-Dog Shaking in Rats by Analogues and Metabolites of Thyrotropin-Releasing Hormone (TRH)", 5 Regulatory Peptides 43 (1982).
Bennett et al., "Analeptic Effect of Intracerebral Injection of TRH and Stabilized Analogues in the Pentobarbitone-Anaesthetized Rat", Proceedings of the British Pharmacological Society (1982).
Heal et al., "Behavioral Effects of Central and Peripheral Injection of Various Analogues and Metabolites of Thyrotropin Releasing Hormone (TRH)", 20 Neuropharmacology 947 (1981).
Friderichs et al., "Activity of Thyroliberin Analogs with a Modified Pyroglutamyl Residue on the Central Nervous System", Structure and Activity of Natural Peptides 462 (1981).
Schwertner et al., "Synthesis of Thyroliberin Analogs with Modified Pyroglutamyl Residues", Structure and Activity of Natural Peptides 397 (1981).
Friderichs et al., "Activity of Thyroliberin Analogs with a Modified Pyroglutamyl Residue on the Central Nervous System", 360 Z. Physiol. Chem. 1146 (1979).
Schwertner et al., "Synthesis of Thyroliberin Analogs with Modified Pyroglutamyl Residues", 360 Z. Physiol. Chem. 1195 (1979).
Yehuda et al., "Effects of TRH and PS-24 on Colonic Temperature and Motor Activity of Rats: Possible Role of Dopamine", Peptides, vol. 2, pp. 131-135 (1981).
"CG 3703", Drugs of the Future, vol. 8, No. 12, pp. 1007-1009 (1981).
Hennies et al., "Effects of the Thyroliberin Analogue CG 3703 on Noradrenergic and Serotoninergic Transmission in Rodents", Biochemical Pharmacology, vol. 31, No. 14, pp. 2430-2432 (1982).
Dettmar et al., "Can Biological Stability Account for the Enhanced CNS Potency of All TRH Analogues?", Thyrotropin-Releasing Hormone 361 (1983).
Griffiths et al., "Mechanisms of Brain Inactivation of Centrally-Acting Thyrotropin-Releasing Hormone (TRH) Analogues", 5 Regulatory Peptides 1-11 (1982).
Bauer, "Thyroliberin Analogues as Competitive Inhibitors of Thyroliberin Degradation by Brain Enzymes", Z. Physiol. Chem. vol. 360, 1126 (1979).
Hennies et al., "Norepinephrine and Serotonin Turnover in Rodents After Application of the TRH Analogue CG 3703", Thyrotropin-Releasing Hormone 371 (1983).
Stezowski et al., "Conformational Properties of TRH and TRH Analogs as Determined by Single Crystal X-Ray Diffraction Techniques", Thyrotropin-Releasing Hormone 385 (1983).
Bauer et al., "Degradation of TRF and TRF Analogues by Brain and Serum Enzymes", Structure and Activity of Natural Peptides 437-47 (1981).
Fukuda et al., "Behavioral and EEG Alterations with Brain Stem Compression and Effect of Thyrotropin Releasing Hormone (TRH) in Chronic Cats", Folia Pharmacol., vol. 75, No. 4, pp. 321-331 (1979).
Barth Hans
Flohe Leopold
Giertz Hubert
Gruenenthal GmbH
Phillips Delbert R.
LandOfFree
Method of treating posttraumatic nervous injuries with dipeptide does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treating posttraumatic nervous injuries with dipeptide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating posttraumatic nervous injuries with dipeptide will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-47512