Method of treating post menopausal osteoporosis with hexafluro-v

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai

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514168, 552653, A61K 3159, A61K 31595

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active

055718027

ABSTRACT:
A method of treating post menopausal osteoporosis which comprises administering to a subject having the disease an effective daily dose of 26,26,26,27,27,27-hexafluoro-1.alpha.,25-dihydroxycholecalciferol compound in an amount from about 0.05 .mu.g to about 2.0 .mu.g.

REFERENCES:
patent: 4248791 (1982-02-01), DeLuca et al.
patent: 4358406 (1982-11-01), DeLuca et al.
patent: 4411833 (1983-10-01), DeLuca et al.
"BioFactors; Vitamin D Research-First International Congress on Vitamins and Biofactors in Life Sciences", DeLuca et al, vol. 3, No. 4, pp. 271, Apr. 1992.
"Bone and Mineral; 26,27-Hexafluoro-1,25-Dihydroxyvitamin D.sub.3 (F6-1,25(OH).sub.2 D.sub.3) Prevents Osteoporosis Induced by Immobilization combined with Ovariectomy in the Rat", Okumura et al, vol. 9, No. 2, pp. 101-109, May 1990.
"Bone and Mineral; Biological Potency of a Fluorinated Vitamin D Analogue in Hypoparathyroidism", Nakatsuka et al, vol. 16, No. 1, pp. 73-81, Jan. 1992.
"Archives of Biochemistry and Biophysics; 26,26,26,27,27,27-Hexafluoro-1,25-Dihydroxyvitamin D.sub.3 : A Highly Potent, Long-Lasting Analog of 1,25-Dihydroxyvitamin D.sub.3 ", Tanaka et al, vol. 229, No. 1, pp. 348-354, 1984.
Tilyard, Murray W. et al., "Treatment of Postmenopausal Osteoporosis With Calcitrol or Calcium", The New England Journal of Medicine, vol. 326, No. 6, pp. 357-362 (1992).
Aloia, John F., M.D. et al, "Calcitrol in the Treatment of Postmenopausal Osteoporosis", The American Journal of Medicine, vol. 84, pp. 401-408 (1988).

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