Method of treating polymicrobial burn wound sepsis with a combin

Details Method of treating polymicrobial burn wound sepsis with a combin Method of treating polymicrobial burn wound sepsis with a combin

1986-10-27

1988-09-20

Shain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

424 858, 530387, 435874, A61K 3940, A61K 39395

Patent

active

047724650

ABSTRACT:
A method for increasing the survival rate in hypercatabolic mammals following the onset of burn wound sepsis. The method comprises orally administering to the mammal, sufficient doses of ciprofloxacin to attain high concentrations in extra vascular fluid, and parenterally administering to the mammal, Pseudomonas immune globulin. The combination therapy of treating Pseudomonas burn wound sepsis with ciprofloxacin and Pseudomonas immune globulin results in a higher rate of survival than the treatment utilizing a single agent. This suggests a synergistic interaction between the two agents in the therapy of polymicrobial burn wound sepsis.

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