Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1998-03-19
2000-03-07
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
424602, 424677, 424682, 424686, 424715, 424722, A61K 3159, A61K 3342, A61K 3310, A61K 3306, A61K 3300
Patent
active
060340754
ABSTRACT:
The present invention is directed to a method of treating polycystic ovarian syndrome (PCO) with calcium alone, with vitamin D alone, or with the combination calcium and vitamin D. This invention further provides a method of treating infertility in a woman which comprises administering to the subject an amount of calcium or a derivative thereof effective to treat the infertility. The present invention is also directed to a method of treating irregular menses (oligo/amenorrhea), acne, or hirsutism, insulin resistance, or infertility which comprises administering a combination of calcium or a derivative thereof and vitamin D or a derivative thereof in an amount effective to treat irregular menses (oligo/amenorrhea), acne, or hirsutism, insulin resistance, or infertility. This invention also provides a method of preventing polycystic ovarian syndrome which comprises administering to the subject a combination of vitamin D or a derivative thereof and calcium or a derivative thereof in an amount effective to prevent the onset of polycystic ovarian syndrome.
REFERENCES:
patent: 4946679 (1990-08-01), Thys-Jacobs
patent: 5354743 (1994-10-01), Thys-Jacobs
Channing CP, Hillensjo T, Schaef FW. Hormonal Control of Oocyte Meiosis, Ovulation and Luteinization in Mammals. Clin Endocrinol Metabol 1978;7:601-624. (Exhibit 4).
Davis JS, Weakland LL, Farese RV, West LA. Luteinizing Hormone Increases Inosital Triphosphate and Cytosolic Free Ca2+ in Isolated Bovine Luteal Cells. J Biol Chem 1987;262:8515-8521. (Exhibit 5).
Homa ST. Calcium and Meiotic Maturation of the Mammalian Oocyte. Mol Reprod Dev 1995;40:122-134. (Exhibit 6).
Jobin RM, Tomic M, Zheng L et al. Gonadotropin-Releasing Hormone-Induced Sensitization of Calcium-Dependent Exocytosis in Pituitary Gonadotrophs. Endocrinology 1995;136:3398-3405. (Exhibit 7).
Mattioli M, Barboni B, Seren E. Luteinizing Hormone Inhibits Potassium Outward Currents in Swine Granulosa Cells by Intracellular Calcium Mobilization. Endocrinology 1991;129:2740-2745. (Exhibit 8).
Powers RD, Paleos GA. Combined effects of calcium and dibutyryl cyclic AMP on germinal vesicle breakdown in the mouse oocyte. J Reprod Fert 1982:66:1-8. (Exhibit 9).
Criares Theodore J.
The Trustees of Columbia University in the City of New York
White John P.
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