Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1998-05-11
1999-03-09
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424486, 424489, 424490, 424491, 424499, 435174, 435177, 435180, 435182, 514866, A61K 948, A61K 950, C12N 1100
Patent
active
058797092
ABSTRACT:
The present invention is directed to a method of treating a patient with diabetes by implanting an improved macrocapsule containing living islet cells in the patient. The improved macrocapsules encapsulate microcapsules containing islet cells, to make the system more biocompatible by decreasing the surface area and surface roughness of microencapsulated biological materials; increasing stability of microencapsulated islet cells; enhancing cytoprotectivity by increasing diffusion distance of encapsulated islet cells from cytotoxins secreted in vivo; providing retrievability of microencapsulated material; and providing a system of sustained release of the cellular products.
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Desai Neil P.
Heintz Roswitha E.
Soon-Shiong Patrick
Kishore Gollamudi S.
Vivorx Inc.
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