Method of treating Parkinson's Disease using pentanedione deriva

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514522, 514565, 514567, 514615, 514678, A01N 3731, A01N 3712, A01N 3744, A01N 3500

Patent

active

051128616

ABSTRACT:
The invention concerns a method for the treatment of Parkinson's Disease. The method comprises administering a catechol-O-methyl-transferase inhibiting amount of a compound having the formula I ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, alkylcarbamoyl of 2 to 5 carbon atoms or alkylcarbonyl of 2 to 5 carbon atoms, X represents nitro or cyano and R.sub.3 represents ##STR2## wherein R.sub.4 represents cyano or alkylcarbonyl of 2 to 5 carbon atoms and R.sub.5 represents cyano; alkylcarbonyl of 2 to 5 carbon atoms; or carbamoyl which is unsubstituted or substituted with alkyl of 1 to 8 carbon atoms, or hydroxyalkyl of 1 to 8 carbon atoms or pharmaceutically acceptable salts or esters thereof; and a sufficient amount of levodopa to treat Parkinson's Disease. A peripheral decarboxylase inhibitor such as carbidopa or benzerazide is also preferably administered.

REFERENCES:
patent: 3804904 (1974-04-01), Bentley et al.
patent: 3886285 (1975-05-01), Bentley et al.
Chemical Abstracts vol. 79, 105449n.
Chemical Abstracts vol. 104, 109112e.
Chemical Abstracts vol. 95, 42542v.
Chemical Abstracts vol. 92, 146461x.
Chemical Abstracts vol. 79, 27554b.
Marck Index pp. 7678 and 7679.
"On the secondary products of the synthesis of vanillin from guaiacol and of ethylvanillin from pyrocatechol monoethyl ether: 4-hydroxy-5-methoxy-and 4-hydroxy-5-ethoxyisophthalaldehydes," Favre, Claude, Chemical Abstracts, vol. 48, 1954, p. 5831.
"Syntheses of heterocyclic compounds, DCXXXV. Nitrenes. IX. Reaction of .beta.-(2-nitrobenzoyl)-2-nitrostyrene derivatives with triethyl phosphite," Kametani, Tetsuji, et al., Chemical Abstracts, vol. 75, 1971, p. 308 (151626h).
"Synthesis of 2,3-dimethoxy-5-methyl-p-benzoquinone," Sato, Kikumasa, et al., Chemical Abstracts, vol. 78, 1973, p. 471 (29377z).
"Catechol O-methyltransferase. 10. 5-Substituted,3-hydroxy-4-methoxybenzoic acids (isovanillic acids) and 5-substituted, 3-hydroxy-4-methoxybenzaldehydes (isovan=illins) as potential inhibitors," Borchardt, Ronald T., et al., Chemical Abstracts, vol. 96, 1982, p. 81807a.
"A useful synthesis of ethyl indole-2-carboxylates and 3,4-dihydrocarboxtyrils" Mali, R. S., et al., Chemical Abstracts, vol. 102, 1985, p. 580 (62028y).
"The effect of ring-fluorination on the rate of O-methylation of dihydroxyphenylalanine (DOPA) by catech=1-O-methyltransferase: significance in the development of F-PETT scanning agents," Creveling, Cyrus R., et al., Chemical Abstracts, vol. 104: 207624t.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of treating Parkinson's Disease using pentanedione deriva does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of treating Parkinson's Disease using pentanedione deriva, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating Parkinson's Disease using pentanedione deriva will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2426234

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.