Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-10-02
2010-06-29
Monshipouri, Maryam (Department: 1656)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
Reexamination Certificate
active
07745402
ABSTRACT:
The present invention provides a method of treating pancreatitis comprising administering to a human in need thereof an effective amount of hemin. The administration of hemin is preferably parenteral. In another aspect, the present invention provides a method of pancreatitis prophylaxis comprising administering to a human in need thereof an effective amount of hemin. In a still further aspect, the present invention contemplates a method of inducing an HO gene comprising administering to a human in need thereof an HO-inducing effective amount of hemin. Preferably, the HO gene is the HO-1 gene. In a still further aspect, the present invention contemplates a method of inducing an HO gene in leukocytes for recruitment to the pancreas to treat pancreatitis comprising administering to a human in need thereof an HO-inducing effective amount of hemin. In another embodiment, the present invention contemplates a method of inducing an HO gene in leukocytes for recruitment to the pancreas for prophylaxis of pancreatitis comprising administering to a human in need thereof an HO-inducing effective amount of hemin. In a yet further aspect, the present invention provides a method of ex vivo treatment of pancreatitis comprising providing peripheral blood leukocytes, followed by contact with hemin to form induced peripheral blood leukocytes then infusing the induced peripheral blood leukocytes into a human in need thereof.
REFERENCES:
patent: 6689745 (2004-02-01), Itakura et al.
patent: 2004/0228930 (2004-11-01), Billiar et al.
Sato et al., FEBS Letters, 1997, 405(2), 219-223.
Rossi et at. “Inhibiton of Human lymphocyte Ferrochelatase Activity” by Hemin. Biochimica et Biophysica Acta (Netherlands), May 8, 1990, V1038(3). p. 375-81 (abstract only).
Wagener et al. “Hemin is a Potent Inducer of Inflammation in Mice and is Counteracted by Heme Oxygenase”. Blood Journal. Sep. 15, 2001. vol. 98(6). p. 1802-1811, p. 1802, 1809.
International Search Report for International Application No. PCT/US06/38509.
Perez-Mateo M. “How We Predict the Etiology of Acute Pancreatitis”. J. Pancreas (online) 2006 7(3) ;257-261.
Gullo M., Migliori M., Olah A., Farkas G., Levy P., Arvanitakis C, et al. “Acute Pancreatitis in Five European Countries; Etiology and Mortality”. Pancreas 202; 24:223-7.
Collins Stephen
Omary Bishr
Lundbeck Inc.
Monshipouri Maryam
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