Method of treating pain by administering 24 hour oral opioid for

Details Method of treating pain by administering 24 hour oral opioid for Method of treating pain by administering 24 hour oral opioid for

1993-11-23

1995-12-26

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424490, 424468, 424457, 424451, 424456, A61K 914

Patent

active

054785774

ABSTRACT:
Patients are treated with 24-hour oral sustained release opioid formulations which upon administration quickly release an effective portion of the opioid contained therein such that there is an initially more rapid opioid release so that the minimum effective analgesic concentration of the opioid can be more quickly achieved. In the method, the formulations are designed to provide a relatively large peak to trough concentration of the opioid, rather than a flattened serum concentration curve.

REFERENCES:
patent: 4797410 (1989-01-01), El Fakahany
patent: 5321012 (1994-06-01), Mayer et al.
patent: 5330766 (1994-07-01), Morella et al.
Advertisement: Roxanol SR, .COPYRGT.1988 Roxane Laboratories, Inc.
R. Kaiko and T. Hunt, "Comparison of the Pharmacokinetic Profiles of Two Oral Controlled-Release Morphine Formulations in Healthy Young Adults", Clin. Thera., vol. 13, No. 4, 1991.
R. West and C. Maccarrone, "Single Dose Pharmacokinetics of a New Oral Sustained-Release Morphine Formulation, Kapanol.RTM. Capsules", Abstracts--7th World Congress on Pain, Aug. 26, 1993, Abstracts 997-1001.
S. Bloomfield, et al., "Analgesic efficacy and potency of two oral controlled-release morphine preparations", Clin. Pharmacol. Ther., vol. 53, No. 4, pp. 469-478, .COPYRGT.1993.
Advertisement: MS Contin.RTM., .COPYRGT.1986, 1987, The Purdue Frederick Company.

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