Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1992-06-29
1994-08-09
Wityshyn, Michael G.
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
A61K 3702
Patent
active
053364880
ABSTRACT:
Cytokines are useful for the ability to improve the natural defense system of the involuting mammary gland. In addition to the immunopotentiating activity, cytokines accelerate the normal physiology of involution of the mammary gland and thereby afford further protection against new infections of mammals. The involuting mammary gland is very susceptible to infection during the early stages of involution and therefore decreasing the period of highest susceptibility while also improving the natural defense mechanisms is of great advantage over most therapies. Used alone, in various cytokine combinations, or in combination with other therapeutics, cytokines protect the mammary gland and cure existing infections and are particularly useful during cessation of lactation and early reinitiating of lactation.
REFERENCES:
patent: 5124145 (1992-06-01), Sordillo et al.
Nickerson et al. J. Dairy Sci. 72:1764-1773 (1989).
Smith et al. J. Dairy Res. 35:287-290 (1968).
Bovine Natural Cell Mediated Cytotoxicity (NCMC): Activation by Cytokines. Veterinary Immunology and Immunopathology, 24 (1990) 113-124. J. Jensen and R. D. Schultz.
Cloning, Sequence and Expression of Two Distinct Human Interleukin-1 Complementary DNAs. Nature vol. 351 (1985) 641-647 Carl J. March et al.
Frequency of Isolation of Environmental Mastitis-Causing Pathogens and Incidence of New Intramammary Infection During the Nonlactating Period. Am J Vet Res, vol. 49: No. 11, (1988) 1789-1793 S. P. Oliver.
Cytokines: Applications in Domestic Food Animals, Journal of Dairy Science vol. 74, No. 1 (1991) 328-339, Frank Blecha.
Infection of Rabbit Mammary Glands with Ovine Mastitis Bacterial Strains, J. Comp. Path. (1991) vol. 104:289-302 B. Amorena et al.
Identification of a Positive Retroregulator that Stabilizes mRNAs in Bacteria, Proc. Natl. Acad. Sci. vol. 83, 3233-3237 (1986), Hing C. Wong and Shing Chang.
Bovine GM-CSF Molecular Cloning and Biological Activity of the Recombinant Protein, Molecular Immunology, vol. 25, No. 9: 843-850 (1988), Charles R. Maliszewsik et al.
Daley Michael J.
Furda Gary J.
Hayes Phillip W.
American Cyanamid Company
Koh Choon P.
Tsevdos Estelle J.
Wityshyn Michael G.
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