Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1991-12-04
1993-03-30
Rollins, John W.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
514821, 514824, A61K 31745
Patent
active
051982110
ABSTRACT:
In accordance with the present invention, a method is provided for treating myocardial damage. More particularly, the present invention relates to a method for treating myocardial damage comprising injecting a non-emulsion, homogeneous solution of certain ethylene oxide-propylene oxide condensation surface-active copolymers.
The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula:
REFERENCES:
patent: 3450502 (1969-06-01), Hymes
patent: 3590125 (1971-06-01), Hymes
patent: 3641240 (1972-02-01), Hymes et al.
patent: 3956259 (1976-05-01), Garcia et al.
patent: 3980772 (1976-09-01), Ginger et al.
patent: 4179337 (1979-12-01), Davis et al.
patent: 4186253 (1980-01-01), Yokoyama et al.
patent: 4305922 (1981-12-01), Rhodes
patent: 4395393 (1983-07-01), Schmolka
patent: 4600652 (1986-07-01), Solomon
patent: 4609546 (1986-09-01), Hiratani
patent: 5028599 (1991-07-01), Hunter
Heron, M. W., et al., "A Method for Measuring a Nonionic Surface-Active Agent (Pluronic F-68) in Biological Fluids," Analytical Biochemistry, vol. 24, pp. 491-495 (1968).
Uno, T., et al., "Determination of Surface-Active Agents. VIII. Infrared Determination of the Proportion of Ethylene Oxide and Propylene Oxide in Pluronic," Chem. Pharm. Bull., vol. 15(1), pp. 77-82 (1967).
Hymes, A. C., et al., "Influence of an industrial surfactant (Pluronic F-68) on human amniotic fluid embolism," American Journal Obstetrics and Gynecology, vol. 107(8), pp. 1217-1222 (1970).
Grover, F. L., et al., "Beneficial Effect of Pluronic F-68 on the Microcirculation in Experimental Hemorrhagic Shock," Surgical Forum, vol. 21, pp. 30-32 (1970).
Maugh, T. H., "Perfluorochemical Emulsions: Promising Blood Substitutes," Science, vol. 179, pp. 669-672 (1973).
Justice, C., et al., "Prevention of Thrombosis with Agents which Reduce Platelet Adhesiveness," The American Surgeon, vol. 40, pp. 186-189 (1974).
Danielson, G., et al., "Use of Pluronic F-68 to Diminish Fat Emboli and Hemolysis During Cardiopulmonary Bypass," The Journal of Thoracic and Cardiovascular Surgery, vol. 59(2), pp. 178-184 (1970).
Ketchum, L. D., "Experimental Use of Pluronic F68 in Microvascular Surgery", (Plastic Reconstructive Surgery), vol. 54 p. 478 (1974).
Schmolka, I., "A Review Of Block Polymer Surfactants", Journal of the American Oil Chemists Society, 54, No. 3, pp. 110-116 (1977).
Block and Graft Copolymerization, vol. 2, (ed. by R. J. Ceresa, John Wiley & Sons, 1976), "The Applications of Block Copolymer Polyol Surfactants", L. G. Lundsted and I. R. Schmolka; pp. 174-205 and pp. 255-272 (references).
Kanter, K. R. et al., "Superiority of perfluorocarbon cardioplegia over blood or crystalloid cardioplegia", Circulation, vol. 64, pp. II-75-II-80 (1981).
Harjula, A., et al., "Perfluorocarbon solution as a myocardial preservative", J. Applied Cardiology, vol. 2, pp. 121-136 (1987).
Hoie, J., et al., "Effects of Pluronic.RTM. F68, Poloralkol, On Vascular Resistance In Vivo", Journal of Surgical Research, vol. 11, pp. 515-517 (1971).
Ketchum, L. D. et al, "Experimental Use Of Pluronic.RTM. F-68 In Microvascular Surgery", Plastic and Reconstructive Surgery, vol. 53, pp. 288-292 (1974).
Benner, K. U., et al, "Cold-Induced Platelet Aggregation In Vivo and Its Inhibition By A Nonionic Surface Active Substance", Thrombosis Research, vol. 2, pp. 331-342 (1973).
Benner, K. U., et al., "Uber die Wirkung von Pluronic.RTM. F68, einem Poloxypropylen-Polyoxyathylen-Kondensat, auf die ADP-induzierte Thrombocytenaggregation in vitro", Pflugers Arch., vol. 315, pp. 45-52 (1970).
Gaehtgens, P. et al., "Disaggregation of Human Red Blood Cells by Various Surface-Active Agents as Related to Changes of Cell Shape and Hemolysis", Act Heamat. vol. 33, pp. 82-89 (1975).
Grover, F. L. et al., "A Nonionic Surfactant And Blood Viscosity", Arch. Surg., vol. 106, pp. 307-310 (1973).
Vasko, K. A., et al., "Poloxalkol.RTM. (Pluronic F-68): A priming solution for cardiopulmonary bypass", Trans. Am. Soc. Artif. Int. Organs, 18, 526-531 (1972).
Organ Perfusion and Preservation, (ed. by Norman, J. C., Appleton-Century-Crofts, (1968), Paton, B. C. et al. "The use of a nonionic detergent added to organ perfusates" pp. 105-120.
Grover, F. L., et al., "The Effect of Pluronic.RTM. F-68 On Circulatory Dynamics And Renal And Carotid Artery Flow During Hemorrhagic Shock", Journal of Surgical Research, vol. 17, pp. 30-35 (1974).
Hymes, A. C., et al., "The Influence Of An Industrial Surfactant Pluronic.RTM. F-68, In The Treatment of Hemorrhagic Shock", Journal of Surgical Research, vol. 11, pp. 191-197 (1971).
Advances in Blood Substitute Research (ed. by Bolin, et al., Alan R. Liss, Inc. New York, (1983)) Sugi, et al., The use of Fluosol-DA (FDA) in emergency situations: a report of 67 clinical cases, Abstract/451.
Vercellotti, G. M., et al., "Activation of Plasma Complement by Perfluorocarbon Artificial Blood: Probable Mechanism of Adverse Pulmonary Reactions in Treated Patients and Rationale for Corticosteroid Prophylaxis", Blood, vol. 59, pp. 1299-1304 (1982).
Forman, M. B., et al., "Reduction of infarct size with intracoronary perfluorochemical in a canine preparation of reperfusion", Circulation, vol. 71, pp. 1060-1068 (1985).
Forman, M. B., et al., "Beneficial long-term effect of intracoronary perfluorochemical on infarct size and ventricular function in a canine reperfusion model", J. Am. Col. of Cardiol., pp. 1082-1090 (May, 1987).
Tokioka, M. D., et al., "Effects of intracoronary infusion of arterial blood or Fluosol-DA 20% on regional myocardial metabolism and function during brief coronary artery occlusions", Laboratory Investigation, vol. 75, pp. 473-481 (1987).
Lane, T. A. et al., "Paralysis of phagocyte migration due to an artificial blood substitute", Blood, vol. 64, pp. 400-405 (1984).
Technical bulletin entitled "Performance Chemicals".
Technical bulletin entitled "Pluronic.RTM. Block copolymer surfactants".
Perfluorochemical Blood Substitutes, Technical Information Ser. No. 5, Jun. 30, 1978, Revised, Jul. 1, 1981. Manufacturer: The Green Cross Corporation.
Patent Cooperation Treaty International Search Report for PCT Patent Application No. PCT/US87/01747.
Patent Cooperation Treaty International Search Report for PCT Patent Application No. PCT/US87/01067.
Duncan Alexander
Hunter Robert L.
Emory University
Rollins John W.
LandOfFree
Method of treating myocardial damage does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treating myocardial damage, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating myocardial damage will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1279705