Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
2006-07-04
2006-07-04
Low, Christopher S. F. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C568S378000, C568S447000, C568S668000, C568S824000, C514S859000, C424S451000, C424S464000, C424S489000
Reexamination Certificate
active
07071228
ABSTRACT:
A method of treating said musculoskeletal and connective tissue inflammations including osteoarthritis and associated articular and periarticular inflammations, and non-articular Rheumatism including capsulitis, tendonitis, fibrositis, and perarticular inflammations is disclosed. The method includes administering to a patient of a therapeutically effective amount of a composition comprising 13-cis-retinoic acid. Preferably, the treatment method includes administering to a patient of an initial dosage of a composition comprising 13-cis-retinoic acid for an initial treatment period, and thereafter administering a maintenance dosage of the composition.
REFERENCES:
patent: 5457129 (1995-10-01), Aggarwal et al.
Cousins et al., Ceruloplasmin and Metallothionein Induction by Zinc and 13-Cis Retinoic-Acid in Rats with Adjuvant Inflammation, Proc Soc Exp Biol Med, (1985) 179(2), 168-172. See: abstract.
Brinckerhoff et al., Inflammation and Collagenase Production in Rats With Adjuvant Arthritis Reduced With 13-Cis-Retinoic Acid, Science (WASH DC), (1983) 221 (4612), 756-458. See: abstract.
Bottomley et al., Acute Achilles Tendon Following Oral Isotretinoin Therapy for Acne Vulgaris, Clinical Experimental Dermatology, 1992, vol. 17, No. 4, pp. 250-251, abstract.
The Physicians Desk Reference, Electronic Edition, ACCUTANE® (Roche Laboratories), (isotretinoin), capsules.
Webster's Ninth New Collegiate Dictionary, Merriam-Webster Inc. Publishers, 1984, p. 1011.
Osteoarthritis or Rheumatoid Arthritis? Know the Difference. http:://www.ra.com/ra/rastore/cgi-bin/PrintFriendly-Cat-200156 MavRoot 303 ProdID 200630htm.
Arthritis and Auto-Immune Disease. http://www.askdoctrish.com/arthritis.htm.
Clinical pharmacokinetics 1985 Jan.-Feb.;10(1) 38-62, Lucek RW, Clinical pharmacokinetics of the retinoids, http://www.ncbl.nim.nih.gov/entrez query.fcgi.
Cancer Research (Jul. 17, 1995);Retinoid-induced suppression of squamous cell differentation in human oral squamous cell crcinoma xenografts (line 1483) in athymic nude mice.
Biochem Pharmacol. May 15, 2003;65(10):1685-90., Gagnon I, et al. Enzymatic Characterization of recombinant mousa retinal dehydrogenase type 1.
Lewis Amy
Li Yi
Low Christopher S. F.
Silverman M. K.
LandOfFree
Method of treating musculoskeletal and connective tissue... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treating musculoskeletal and connective tissue..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating musculoskeletal and connective tissue... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3526297