Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2005-05-13
2010-06-29
Ewoldt, G. R (Department: 1644)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
active
07744894
ABSTRACT:
Methods for blocking autoreactive T cell-initiated destruction of tissues in a mammal are provided. In one embodiment, the methods involve administering an HAS/CD24 polypeptide or fragment thereof. In some embodiments, the polypeptide or fragment is glycosylated.
REFERENCES:
patent: 5225538 (1993-07-01), Capon
patent: 5593826 (1997-01-01), Fung et al.
patent: 5643570 (1997-07-01), Theofan et al.
patent: 5952471 (1999-09-01), Lawson et al.
patent: 6300492 (2001-10-01), Korneluk et al.
patent: 6379670 (2002-04-01), Gaur et al.
patent: 6656466 (2003-12-01), Etcheverry et al.
patent: 7232566 (2007-06-01), June
patent: 01/72325 (2001-10-01), None
patent: 2005/054810 (2005-06-01), None
Kay, R., et al. J. Immunol. Aug. 1991;147(4):1412-1416.
Zhou, Q., et al. PNAS. 2003;100(25):15041-15046.
Liu, Y., et al. Trends in Immunol. 2007;28(7):315-320.
Liu, J.Q., et al J. Immunol. 2007;178:6227-6235.
Abstract—Gupta, “Sequence and Structural Homology Between a Mouse T Complex Protein TCP-1 and the Chaperonin Family of Bacterial Groel 60-65-KDA Heat Shock Antigen and Eukaryotic Proteins”,Biochem Int. (1990) vol. 20, No. 4, pp. 833-841.
Bai et al., “The heat-stable antigen determines pathogenicity of self-reactive T cells in experimental autoimmune encephalomyelitis”,The Journal of Clinical Investigation(2000) vol. 105, No. 9, pp. 1127-1232.
Wither et al., “Genetic dissection of B cell traits in New Zealand black mice. The expanded population of B cells expressing up-regulated costimulatory molecules shows linkage toNba2”, Eur. J. Immunol(2000) vol. 30, pp. 356-365.
Springer, TA, “Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm” Cell 76: 301-314 (1994).
Salamone, et al., “Antibodies recognizing CD24 LAP epitope on human T cells enhance CD28 and IL-2 T cell proliferation”, J. of Leukocyte Biology, vol. 69, Feb. 2001, pp. 215-223.
Zhou, Q., et al., “Homotypic interaction of the heat-stable antigen is not responsible for its co-stimulatory actdivity for T cell clonal expansion”, Eur. J. Immunol. 27: 2524-2528, (1997).
Zamvil, SS et al., “The T lymphocyte in experimental allergic encephalomyelitis”, Annu. Rev. Immunol. 8: 579-621 (1990).
Wu, Y., et al., “CD28-independent induction of T helper cells and immunoglobulin class switches requires costimulation by the heat-stable antigen”, J. Exp. Med. 187: 1151-1156 (1998).
Wu, TC et al., “A reassessment of the role of B7-1 expression in tumor rejectdion”, J. Exp. Med. 182: 1415-1421 (1995).
Wang, Y-C., et al. “Expression of heat-stable antigen on tumor cells provides co-stimulation for tumor-specific T cell proliferation and cytotoxicity in mice”, Eur. J. Immunol. 25: 1163-1167 (1995).
Vyse, TJ et al., “Genetic analysis of autoimmune disease”, Cell 85: 311-318 (1996).
Vanderlugt, CL et al., “The functional significance of epitope spreading and its regulation by co-stimulatory molecules”, Immunol. Rev. 164: 63-72 (1998).
Tselios et al., “Antagonistic effects of human cyclic MBP (87-99) altered peptide ligands in experimental allergic encephalomyelitis and human T-cell proliferation”, J. of Medicinal Chemistry 45: 275-283, (2002).
Zarn et al. “The small cell lung cancer antigen cluster-4 and the leukocyte antigen CD24 are allelic isoforms of the same gene (CD24) on chromosome band 6q21”, Cytogenet Cell Genet 70: 119-125 (1995).
Allison, J., et al., “The threshold for autoimmune T cell killing is influenced by B7-1”, Eur. J. Immunol. 28: 949-960, (1998).
Baron, JL, et al., “Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma”, J. Exp. Med. 177: 57-68 (1993).
Becker, KG et al., “Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases”, Proc. Natl. Acad. Sci, USA 95: 9979-9984 (1998).
Meulenbroek AJ & Zeijlemarker WP (1996) Human IgG Subclasses: Useful diagnostic markers for immunocompetence Sanquin formerly, Sections 1 through 2.3, http://www.xs4all.nl/˜ednieuw/IgGsubclasses/subkl.htm, published by CLB, 1996, The Netherlands, ISBN 90-5267-011-0 Internet Page By Ed Nieuwenhuys, 14 pgs.
Chaffin, KE, et al., “Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase”, EMBO J. 9: 3821-3829 (1990).
Chang, TT, et al., “Studies in B7-deficient Mice Reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis”, J. Exp. Med. 190: 733-740 (1999).
Chong, H., et al., “Expression of B7 co-stimulatory molecules by B16 melanoma results in a natural killer cell-dependent local anti-tumour response, but induces T-cell-dependent systemic immunity only against B7-expressing tumours”, Br. J. Cancer, 78: 1043-1050 (1998).
Crispe, IN, et al., “Expression and functional significance of the J 11 d marker on mouse thymocytes”, J. Immunol. 138: 2013-2018 (1987).
Cross et al., “Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation”, J. of Clinical Investigation 95: 2783-2789, (Jun. 1995).
DeBruijn, JL et al., “Induction of heat-stable antigen-expression by phagocytosis is involved in in vitro activation of unprimed CTL by macrophages”, J. Immunol. 156: 2686-2692 (1996).
Engelhardt, B., et al., “E-and P-selectin are not involved in the recruitment of inflammatory cells across the blood-brain barrier in experimental autoimmune encephalomyelitis”, Blood, 90: 4459-4472 (1997).
Jefferis, R., Molecular Structure of Human IgG Subclasses, pp. 15-31, In: Shakib F, ed. The Human IgG subclasses, Pergamon press. 1990.
Kadmon, G., et al, “Nectadrin, the heat-stable antigen, is a cell adhesion molecule”, J. Cell. Biol 188: 1245-1253 (1992).
Kerlero de Rosbo, N., et al., “Chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in PL/J mice by myelin oligodendrocyte glycoprotein (MOG)-derived peptide: preliminary analysis of MOG T cell epitopes”, Eur. J. Immunol. 25: 985-993 (1995).
Lafaille, JJ et al., “Myelin basic protein-specific T helper 2 (th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease”, J. Exp. Med 186: 307-312 (1997).
Liu, Y, et al., “Co-stimulation of murine CD4 T cell growth: cooperation between B7 and heat-stable antigen”, Eur. J. Immunol. 22: 2855-2859 (1992).
Liu, Y, et al., “Heat stable antigen is a costimulatory molecule for CD4 T cell growth”, J. Exp. Med. 175: 437-445 (1992).
Liu, Y, et al., “Distinct costimulatory molecules are required for the induction of effector and memory cytotoxic T lymphocytes”, J. Exp. Med. 185: 251-262 (1997).
Mendel, I., et al., “A myelin oligodendrocyte glocyprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells”, Eur. J. Immunol. 25: 1951-1959 (1995).
Miller, SD et al., “Evolution of the T-cell repertoire during the course of experimental immune-mediated demyelinating diseases”, Immunol. Rev. 144: 225-244 (1995).
Miller, RA et al., “Early activation defects in T lymphocytes from aged mice”, Immunol. Rev. 160: 79-90 (1997).
Oliveira-dos-Santos, AJ et al., “CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitis”, J. Immunol. 162: 4490-4495, (1999).
Ramarathinam, L., et al. “T cell costimulation by B7/BB1 induces CD8 T cell-dependent tumor rejectdion: an important role of B7/BB1 in the induction, recruitment, and effector fu
Bai Xuefeng
Liu Yang
Zheng Pan
Ewoldt G. R
Galant Ron
Polsinelli Shughart PC
Scott Teddy C.
LandOfFree
Method of treating multiple sclerosis and related t-cell... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treating multiple sclerosis and related t-cell..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating multiple sclerosis and related t-cell... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4159010