Method of treating mouse carrying human hepatocytes

Details Method of treating mouse carrying human hepatocytes Method of treating mouse carrying human hepatocytes

2011-01-18

2011-01-18

Allen, Marianne P (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C435S370000, C424S093700

Reexamination Certificate

active

07871980

ABSTRACT:
Human adult hepatocytes are transplanted into an immunodeficient hepatopathy mouse and then human growth hormone is administered to the mouse to thereby elevate twice or more the replacement ratio by the human adult hepatocytes having been transplanted. Further, human growth hormone is administered to an immunodeficient hepatopathy mouse carrying human young hepatocytes transplanted thereinto so as to improve fatty liver of the mouse in which about 70% or more of the hepatocytes have been replaced by the human hepatocytes.

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Tateno et al., American Journal of Pathology, 165(3):901-912, Sep. 2004.
Masumoto et al., Journal of Endocrinology, 194:529-537, 2007.

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