Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1997-03-05
1998-02-24
Prior, Kimberly J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
A61K40100
Patent
active
057212244
ABSTRACT:
18-nor-vitamin D.sub.3 analogs in which the angular methyl group attached to carbon 13 of the CD-ring has been removed and replaced by a hydrogen atom. The 18-nor vitamin D compounds are characterized by relatively high cell differentiation activity, while exhibiting much lower activity than 1.alpha.,25-dihydroxyvitamin D.sub.3 in their ability to mobilize calcium from bone. These compounds would be useful for the treatment of diseases where bone formation is desired, such as osteoporosis, because of their preferential calcemic activity, and for the treatment of psoriasis due to their cell differentiation activity.
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Biorganic & Medicinal Chemistry Letters, vol. 3, No. 9, pp. 1855-1858, 1993, "Synthesis and Biological Evaluation of 18-Substituted Analogs of 1 .alpha.,25-Dihydroxyvitamin D.sub.3 ", Nilsson et al.
J. Org. Chem., vol. 57, No. 11, pp. 3214-3217, 1992, "18-Substituted Derivatives of Vitamin D: 18-Acetoxy-1.alpha.,25-Dihydroxyvitamin D.sub.3 and Related Analogues", Maynard et al.
DeLuca Hector F.
Perlman Kato L.
Sicinski Rafal R.
Prior Kimberly J.
Wisconsin Alumni Research Foundation
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