Method of treating mammalian joint maladies by biological...

Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Body fluid or exudate or transudate other than snake venom,...

Reexamination Certificate

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C424S520000, C424S548000, C424S400000

Reexamination Certificate

active

10727893

ABSTRACT:
Disclosed is a product and method for transplanting biological fluids into a host animal (including humans) that have been collected from donor animals. These biological fluids have been purified and processed so that they are a cellular, sterile, pathogen free, and a form that can be stored for considerable periods of time without degradation. In one embodiment, synovial fluid is harvested from a large number of donors to produce the transplantation compound. Donor fluid is collected from a number of joints per animal, and initially screened for obvious abnormalities (clarity, color, viscosity . . . etc.) and accepted or rejected on a joint-by-joint basis at the time of collection. The collected fluid is frozen in the field. Once in a laboratory setting, the fluid is warmed and spun down in a centrifuge. The supernate is collected, filtered, and mixed in large batches while the permeate is discarded. The supernate is re-frozen, lyophilized (freeze-dried) to form a cake and packaged as an individual dose under vacuum. The product is sterile, stable, has a long shelf life and can be readily reconstituted and injected into a joint.

REFERENCES:
patent: 4620908 (1986-11-01), Van Duzer
Marshall, Wayne K. Intra-articular hyaluronan therapy. Current Opinion in Rheumatology. vol. 12 No. 5 Sep. 2000 pp. 468-474.
Tayal Rishi et al. Comparative Evaluation of efficacy of intra-articular administration of dimethylsufloxide with and without synovial fluid.
PCT International Search Report PCT US 03/38586 May 17, 2004.
Rulcker, C. and Lindholm, A. Preliminary trial of synovial fluid transfer for treating joint lameness in Standardbreds, Equine Vet. Journal. vol. 13 No. 4, (1981) pp. 264-266.

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