Method of treating malaria with desbutylhalofantrine

Details Method of treating malaria with desbutylhalofantrine Method of treating malaria with desbutylhalofantrine

1996-08-23

1998-01-27

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

514895, A61K 948

Patent

active

057119660

ABSTRACT:
This invention provides a method of treating patients suffering from malaria whilst avoiding cardioarrhythmias, the improvement thereof comprising the administration of desbutylhalofantrine in place of halofantrine. Dosage of 500 mg every six hours for three doses on day one with repeat of that dosage on day 7 for a total dosage of 3000 mg is appropriate for most treatment purposes in adults. Desbutylhalofantrine may also be given at dosage of 50 to 1000 mg as a prophylactic measure. Dosage may be given daily or one day per week.

REFERENCES:
patent: 5250234 (1993-10-01), Rossignol et al.
Colwell, et al., Journal of Medicinal Chemistry, 1972, vol. 15, No. 7.

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